polycyclic aromatic hydrocarbons (PAH), a group of persistent organic pollutants, associated with impaired immune function and low-grade inflammation in adults and children. However, the potential for causing a cytokine storm PAH associated with AHR (aryl hydrocarbon receptor) and NLRP3 (NLR family pyrin domain containing 3) in Human has been poorly studied. We aim to determine the relationship between exposure to PAH, AHR and NLRP3 expression, and cytokines associated with cytokine storm in healthy infants. demographic survey and a basic physical examination conducted on 248 preschoolers from electronic waste (e-waste) recycling area (Guiyu, n = 121) and the reference area (Haojiang, n = 127).
concentration of ten urinary PAH metabolites (OH-PAH) was measured. We also measure the level of expression of AHR and NLRP3 and seventeen levels of serum cytokines. several OH-PAH concentrations were significantly higher in the exposed group than in the reference group, especially 1-hydroxynaphthalene (1-OH-Nap) and 2-hydroxynaphthalene (2-OH-Nap). PAH exposure is closely related to the environment and hygiene habits of children. the level of expression of AHR and NLRP3 was significantly higher in the exposed group compared to the reference group. Similarly, serum IL -1β, IL -4, IL -5, IL -10, IL – 12p70 , IL -13, IL -17A, IL -18, < em> IL -22, IL -23, and IFN-γ were notably higher in children exposed e-waste than children of reference.
After adjusting for age, sex, BMI, family income, parental education, and traces of smoke exposure, we found that increased exposure to high PAH associated with AHR and NLRP3 expression and elevated IL -4, < em> IL -10, IL – 12p70 , IL -18, IL -22, IL -23, TNF-α, and IFN-γ levels. The relationship between PAH exposure and IL -1β, IL -18, IFN-γ and TNF-β are mediated by the expression of NLRP3, and the relationship between PAH exposure and IL -4, IL -10, IL – 12p70 , IL -22, IL -23, and TNF-α-mediated expression of AHR. Our findings indicate that the association between PAH exposure and can be mediated by cytokine storms and NLRP3 AHR expression among preschoolers.
Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.
Aryl hydrocarbon receptor (AHR) is the environmental sensors and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and induction of tolerance to modulate immune cells. Such as dendritic cells (DC) express high levels of AHR, they efficiently induce immunomodulatory effects after exposure to AHR-activating compound derived from the environment or diet.
To gain new insights into the molecular target of AHR-activation following in Human monocyte-derived (mo) DC, we investigated whether natural or synthetic quercetin ligand AHR ligand 2,3,7,8-tetrachlorodibenzo p -dioxin (TCDD) to modulate the function of human moDCs regarding their ability to naive T cells prime or to migrate. Because only quercetin, but not TCDD, impaired T cell activation and migration of LPS-matured DC (LPS-DC), we analyzed the mode of action of quercetin on moDCs in more detail.
Interleukin 1 Alpha (IL1a) Antibody |
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20-abx104904 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101891 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101892 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173020 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173021 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173022 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173023 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173024 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177052 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177054 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177055 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx210848 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx211106 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx132312 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx326469 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx113230 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx018000-100ug | Abbexa | 100 ug | EUR 460.8 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx036412-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101885 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101886 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101887 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx101888 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101889 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101890 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx128132 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129396 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129503 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131946 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131947 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131948 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131949 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131950 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131951 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx001782 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx300512 | Abbexa |
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Interleukin-1 Alpha (IL1A) Antibody |
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20-abx225241 | Abbexa |
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IL1A (untagged)-Human interleukin 1, alpha (IL1A) |
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SC324639 | Origene Technologies GmbH | 10 µg | Ask for price |
Active Interleukin 1 Alpha (IL1a) |
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4-APA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-100ug | Biomatik Corporation | 100ug | EUR 1022.9 |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-1mg | Biomatik Corporation | 1mg | EUR 4001.4 |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-50ug | Biomatik Corporation | 50ug | EUR 639.5 |
Active Interleukin 1 Alpha (IL1a) |
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RPU54864-100ug | Biomatik Corporation | 100ug | EUR 985.6 |
Active Interleukin 1 Alpha (IL1a) |
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RPU54864-1mg | Biomatik Corporation | 1mg | EUR 4368 |
Active Interleukin 1 Alpha (IL1a) |
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RPU54864-50ug | Biomatik Corporation | 50ug | EUR 792 |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065654h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065694h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-YP011613HUc7 | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in Yeast |
Interleukin 1 Alpha (IL1a) Antibody (APC) |
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20-abx177053 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx108418 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx300513 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx106997 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody Pair |
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abx117488-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370238 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370358 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370543 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370642 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (FITC) |
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20-abx273853 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx300514 | Abbexa |
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IL1A (GFP-tagged) - Human interleukin 1, alpha (IL1A) |
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RG202084 | Origene Technologies GmbH | 10 µg | Ask for price |
Il1a (GFP-tagged) - Mouse interleukin 1 alpha (Il1a) |
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MG203602 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca01 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca02 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Cp01 | Cloud-Clone |
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Description: Recombinant Goat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Eq01 | Cloud-Clone |
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Description: Recombinant Horse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Gu01 | Cloud-Clone |
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Description: Recombinant Guinea pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu02 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ra01 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58619-100ug | Biomatik Corporation | 100ug | EUR 602.3 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58619-1mg | Biomatik Corporation | 1mg | EUR 2795.5 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58619-50ug | Biomatik Corporation | 50ug | EUR 468.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU59469-100ug | Biomatik Corporation | 100ug | EUR 403.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU59469-1mg | Biomatik Corporation | 1mg | EUR 1755 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU59469-50ug | Biomatik Corporation | 50ug | EUR 288 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58406-100ug | Biomatik Corporation | 100ug | EUR 551.1 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58406-1mg | Biomatik Corporation | 1mg | EUR 2558.4 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU58406-50ug | Biomatik Corporation | 50ug | EUR 428.5 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42162-100ug | Biomatik Corporation | 100ug | EUR 611.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42162-1mg | Biomatik Corporation | 1mg | EUR 2707.9 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42162-50ug | Biomatik Corporation | 50ug | EUR 490.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42163-100ug | Biomatik Corporation | 100ug | EUR 640.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42163-1mg | Biomatik Corporation | 1mg | EUR 2839.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42163-50ug | Biomatik Corporation | 50ug | EUR 514.8 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42164-100ug | Biomatik Corporation | 100ug | EUR 616 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42164-1mg | Biomatik Corporation | 1mg | EUR 2730 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42164-50ug | Biomatik Corporation | 50ug | EUR 495 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42165-100ug | Biomatik Corporation | 100ug | EUR 628.1 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42165-1mg | Biomatik Corporation | 1mg | EUR 2784.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42165-50ug | Biomatik Corporation | 50ug | EUR 504.9 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42166-100ug | Biomatik Corporation | 100ug | EUR 380.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42166-1mg | Biomatik Corporation | 1mg | EUR 1497.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42166-50ug | Biomatik Corporation | 50ug | EUR 230.4 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42167-100ug | Biomatik Corporation | 100ug | EUR 599.5 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42167-1mg | Biomatik Corporation | 1mg | EUR 2653.3 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42167-50ug | Biomatik Corporation | 50ug | EUR 480.7 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42168-100ug | Biomatik Corporation | 100ug | EUR 578.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42168-1mg | Biomatik Corporation | 1mg | EUR 2566.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU42168-50ug | Biomatik Corporation | 50ug | EUR 465.3 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU50480-100ug | Biomatik Corporation | 100ug | EUR 393.8 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU50480-1mg | Biomatik Corporation | 1mg | EUR 1747.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU50480-50ug | Biomatik Corporation | 50ug | EUR 316.8 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53380-100ug | Biomatik Corporation | 100ug | EUR 552.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53380-1mg | Biomatik Corporation | 1mg | EUR 2446.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53380-50ug | Biomatik Corporation | 50ug | EUR 443.3 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53381-100ug | Biomatik Corporation | 100ug | EUR 552.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53381-1mg | Biomatik Corporation | 1mg | EUR 2446.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU53381-50ug | Biomatik Corporation | 50ug | EUR 443.3 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU51132-100ug | Biomatik Corporation | 100ug | EUR 468.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU51132-1mg | Biomatik Corporation | 1mg | EUR 2074.8 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU51132-50ug | Biomatik Corporation | 50ug | EUR 376.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54450-100ug | Biomatik Corporation | 100ug | EUR 601.7 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54450-1mg | Biomatik Corporation | 1mg | EUR 2665 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54450-50ug | Biomatik Corporation | 50ug | EUR 482.9 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54555-100ug | Biomatik Corporation | 100ug | EUR 611.6 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54555-1mg | Biomatik Corporation | 1mg | EUR 2707.9 |
Recombinant Interleukin 1 Alpha (IL1a) |
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RPU54555-50ug | Biomatik Corporation | 50ug | EUR 490.6 |
Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271654 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271680 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271911 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx105579 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273056 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273137 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273464 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274415 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274447 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274500 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274526 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx300515 | Abbexa |
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Interleukin-1 Alpha (IL1A-S87) Antibody |
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abx033026-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin-1 Alpha (IL1A-S87) Antibody |
|||
abx033026-80l | Abbexa | 80 µl | EUR 343.2 |
Canine Interleukin-1 alpha (IL-1a) ELISA Kit, 96 tests, Quantitative |
|||
10475 | Alpha Diagnostics | 1 Kit | EUR 927.6 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
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CAU30264-100ul | Biomatik Corporation | 100ul | EUR 254.4 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU30264-200ul | Biomatik Corporation | 200ul | EUR 317.5 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28733-100ul | Biomatik Corporation | 100ul | EUR 179 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28733-200ul | Biomatik Corporation | 200ul | EUR 219 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28734-100ul | Biomatik Corporation | 100ul | EUR 254.4 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28734-200ul | Biomatik Corporation | 200ul | EUR 317.5 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28735-100ul | Biomatik Corporation | 100ul | EUR 217.9 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28735-200ul | Biomatik Corporation | 200ul | EUR 272.2 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28736-100ul | Biomatik Corporation | 100ul | EUR 217.9 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28736-200ul | Biomatik Corporation | 200ul | EUR 272.2 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28737-100ul | Biomatik Corporation | 100ul | EUR 211.2 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28737-200ul | Biomatik Corporation | 200ul | EUR 263.8 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28738-100ul | Biomatik Corporation | 100ul | EUR 212.2 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28738-200ul | Biomatik Corporation | 200ul | EUR 265.4 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28739-100ul | Biomatik Corporation | 100ul | EUR 241.9 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28739-200ul | Biomatik Corporation | 200ul | EUR 302.4 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28740-100ul | Biomatik Corporation | 100ul | EUR 261.1 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28740-200ul | Biomatik Corporation | 200ul | EUR 325.9 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28741-100ul | Biomatik Corporation | 100ul | EUR 261.1 |
Interleukin 1 Alpha (IL1a) Polyclonal Antibody |
|||
CAU28741-200ul | Biomatik Corporation | 200ul | EUR 325.9 |
Here, we find the specific down-regulation of CD83 molecule immunomodulators through direct binding of AHR is activated for CD83 promoter. In addition, treatment of LPS-DC with quercetin resulted in reduced production of pro-inflammatory cytokines IL – 12p70 and the increased expression of molecules immunoregulatory protein adapter is disabled (Dab) 2, immunoglobulin-like transcript ( IL T) -3, IL T4, IL T5 and ectonucleotidases CD39 and CD73, thereby inducing tolerogenic phenotype in the DC maturing quercetin-treated ,