Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.

polycyclic aromatic hydrocarbons (PAH), a group of persistent organic pollutants, associated with impaired immune function and low-grade inflammation in adults and children. However, the potential for causing a cytokine storm PAH associated with AHR (aryl hydrocarbon receptor) and NLRP3 (NLR family pyrin domain containing 3) in Human has been poorly studied. We aim to determine the relationship between exposure to PAH, AHR and NLRP3 expression, and cytokines associated with cytokine storm in healthy infants. demographic survey and a basic physical examination conducted on 248 preschoolers from electronic waste (e-waste) recycling area (Guiyu, n = 121) and the reference area (Haojiang, n = 127).

concentration of ten urinary PAH metabolites (OH-PAH) was measured. We also measure the level of expression of AHR and NLRP3 and seventeen levels of serum cytokines. several OH-PAH concentrations were significantly higher in the exposed group than in the reference group, especially 1-hydroxynaphthalene (1-OH-Nap) and 2-hydroxynaphthalene (2-OH-Nap). PAH exposure is closely related to the environment and hygiene habits of children. the level of expression of AHR and NLRP3 was significantly higher in the exposed group compared to the reference group. Similarly, serum IL -1β, IL -4, IL -5, IL -10, IL – 12p70 , IL -13, IL -17A, IL -18, < em> IL -22, IL -23, and IFN-γ were notably higher in children exposed e-waste than children of reference.

After adjusting for age, sex, BMI, family income, parental education, and traces of smoke exposure, we found that increased exposure to high PAH associated with AHR and NLRP3 expression and elevated IL -4, < em> IL -10, IL – 12p70 , IL -18, IL -22, IL -23, TNF-α, and IFN-γ levels. The relationship between PAH exposure and IL -1β, IL -18, IFN-γ and TNF-β are mediated by the expression of NLRP3, and the relationship between PAH exposure and IL -4, IL -10, IL – 12p70 , IL -22, IL -23, and TNF-α-mediated expression of AHR. Our findings indicate that the association between PAH exposure and can be mediated by cytokine storms and NLRP3 AHR expression among preschoolers.

Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.
Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.

Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.

Aryl hydrocarbon receptor (AHR) is the environmental sensors and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and induction of tolerance to modulate immune cells. Such as dendritic cells (DC) express high levels of AHR, they efficiently induce immunomodulatory effects after exposure to AHR-activating compound derived from the environment or diet.

To gain new insights into the molecular target of AHR-activation following in Human monocyte-derived (mo) DC, we investigated whether natural or synthetic quercetin ligand AHR ligand 2,3,7,8-tetrachlorodibenzo p -dioxin (TCDD) to modulate the function of human moDCs regarding their ability to naive T cells prime or to migrate. Because only quercetin, but not TCDD, impaired T cell activation and migration of LPS-matured DC (LPS-DC), we analyzed the mode of action of quercetin on moDCs in more detail.

Interleukin 1 Alpha (IL1A) Antibody

abx036412-100ug 100 ug
EUR 391
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Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-b-48T 48T
EUR 493
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Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-b-96T 96T
EUR 641
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Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-c-48T 48T
EUR 474
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Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-c-96T 96T
EUR 614
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Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Eq-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Eq-96T 96T
EUR 654
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Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-g-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-g-96T 96T
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Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Hu-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Hu-96T 96T
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Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Mu-48T 48T
EUR 435
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Mu-96T 96T
EUR 561
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-p-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-p-96T 96T
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Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Ra-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Ra-96T 96T
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Rb-48T 48T
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Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Rb-96T 96T
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Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Alpha (IL1a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-b-48Tests 48 Tests
EUR 516

Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-b-96Tests 96 Tests
EUR 716

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-c-48Tests 48 Tests
EUR 493

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-c-96Tests 96 Tests
EUR 683

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Eq-48Tests 48 Tests
EUR 528

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Eq-96Tests 96 Tests
EUR 733

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-g-48Tests 48 Tests
EUR 528

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-g-96Tests 96 Tests
EUR 733

Human Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Hu-48Tests 48 Tests
EUR 436

Human Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Hu-96Tests 96 Tests
EUR 601

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Mu-48Tests 48 Tests
EUR 447

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Mu-96Tests 96 Tests
EUR 618

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-p-48Tests 48 Tests
EUR 516

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-p-96Tests 96 Tests
EUR 716

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Ra-48Tests 48 Tests
EUR 315

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Ra-96Tests 96 Tests
EUR 429

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Rb-48Tests 48 Tests
EUR 470

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Rb-96Tests 96 Tests
EUR 651

Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-b-48Tests 48 Tests
EUR 494

Bovine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-b-96Tests 96 Tests
EUR 684

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-c-48Tests 48 Tests
EUR 472

Canine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-c-96Tests 96 Tests
EUR 653

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Eq-48Tests 48 Tests
EUR 505

Equine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Eq-96Tests 96 Tests
EUR 700

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-g-48Tests 48 Tests
EUR 505

Goat Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-g-96Tests 96 Tests
EUR 700

Human Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Hu-48Tests 48 Tests
EUR 418

Human Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Hu-96Tests 96 Tests
EUR 575

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Mu-48Tests 48 Tests
EUR 429

Mouse Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Mu-96Tests 96 Tests
EUR 591

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-p-48Tests 48 Tests
EUR 494

Porcine Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-p-96Tests 96 Tests
EUR 684

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Ra-48Tests 48 Tests
EUR 302

Rat Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Ra-96Tests 96 Tests
EUR 411

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Rb-48Tests 48 Tests
EUR 450

Rabbit Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Rb-96Tests 96 Tests
EUR 622

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Gu-48T 48T
EUR 474
  • Should the Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Alpha (IL1a) in samples from serum, plasma or other biological fluids.

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

DLR-IL1a-Gu-96T 96T
EUR 614
  • Should the Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Alpha (IL1a) in samples from serum, plasma or other biological fluids.

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Gu-48Tests 48 Tests
EUR 493

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

RDR-IL1a-Gu-96Tests 96 Tests
EUR 683

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Gu-48Tests 48 Tests
EUR 472

Guinea pig Interleukin 1 Alpha (IL1a) ELISA Kit

RD-IL1a-Gu-96Tests 96 Tests
EUR 653

Human Interleukin-1 alpha (IL1A)

1-CSB-RP065654h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 45 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli

Human Interleukin-1 alpha (IL1A)

1-CSB-RP065694h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
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  • 50ug
  • MW: 22 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli

Human Interleukin-1 alpha (IL1A)

1-CSB-YP011613HUc7
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
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  • MW: 20.0 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in Yeast

Active Interleukin 1 Alpha (IL1a)

4-APA071Hu01
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q53QF9
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 21.2kDa
  • Isoelectric Point: 6.5
Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli

Interleukin 1 Alpha (IL1a) Antibody

20-abx177052
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Interleukin 1 Alpha (IL1a) Antibody

20-abx177054
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  • EUR 133.00
  • EUR 1288.00
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  • EUR 342.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx177055
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Interleukin 1 Alpha (IL1A) Antibody

20-abx210848
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Interleukin 1 Alpha (IL1A) Antibody

20-abx211106
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101885
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  • EUR 133.00
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  • EUR 634.00
  • EUR 342.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101886
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  • EUR 272.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101887
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  • EUR 258.00
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Interleukin 1 Alpha (IL1A) Antibody

20-abx101888
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  • EUR 328.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101889
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101890
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  • EUR 328.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101891
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Interleukin 1 Alpha (IL1a) Antibody

20-abx101892
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  • EUR 342.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx104904
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  • EUR 328.00
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Interleukin 1 Alpha (IL1A) Antibody

20-abx113230
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  • EUR 398.00
  • 150 ul
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Interleukin 1 Alpha (IL1a) Antibody

20-abx128132
  • EUR 398.00
  • EUR 133.00
  • EUR 1094.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
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  • 1 mg
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Interleukin 1 Alpha (IL1a) Antibody

20-abx129396
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
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Interleukin 1 Alpha (IL1a) Antibody

20-abx129503
  • EUR 300.00
  • EUR 133.00
  • EUR 773.00
  • EUR 411.00
  • EUR 258.00
  • 100 ug
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  • 1 mg
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Interleukin 1 Alpha (IL1a) Antibody

20-abx131946
  • EUR 356.00
  • EUR 926.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
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  • Shipped within 5-7 working days.

Interleukin 1 Alpha (IL1a) Antibody

20-abx131947
  • EUR 314.00
  • EUR 787.00
  • EUR 411.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
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Interleukin 1 Alpha (IL1a) Antibody

20-abx131948
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
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  • Shipped within 5-12 working days.

Interleukin 1 Alpha (IL1A) Antibody

20-abx131949
  • EUR 356.00
  • EUR 926.00
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  • EUR 272.00
  • 100 ug
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Interleukin 1 Alpha (IL1A) Antibody

20-abx131950
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Interleukin 1 Alpha (IL1A) Antibody

20-abx131951
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Interleukin 1 Alpha (IL1a) Antibody

20-abx132312
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Interleukin 1 Alpha (IL1A) Antibody

20-abx109930
  • EUR 411.00
  • EUR 1845.00
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  • 100 ug
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  • Shipped within 5-10 working days.

Interleukin 1 Alpha (IL1a) Antibody

20-abx173020
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  • 1 mg
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Interleukin 1 Alpha (IL1a) Antibody

20-abx173021
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Interleukin 1 Alpha (IL1a) Antibody

20-abx173022
  • EUR 913.00
  • EUR 467.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx173023
  • EUR 913.00
  • EUR 467.00
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Interleukin 1 Alpha (IL1a) Antibody

20-abx173024
  • EUR 954.00
  • EUR 481.00
  • 1 mg
  • 200 ug
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Interleukin 1 Alpha (IL1A) Antibody

abx011004-100ul 100 ul
EUR 411
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Interleukin 1 Alpha (IL1A) Antibody

abx033027-400ul 400 ul
EUR 523
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Interleukin 1 Alpha (IL1A) Antibody

abx033027-80l 80 µl
EUR 286
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Here, we find the specific down-regulation of CD83 molecule immunomodulators through direct binding of AHR is activated for CD83 promoter. In addition, treatment of LPS-DC with quercetin resulted in reduced production of pro-inflammatory cytokines IL – 12p70 and the increased expression of molecules immunoregulatory protein adapter is disabled (Dab) 2, immunoglobulin-like transcript ( IL T) -3, IL T4, IL T5 and ectonucleotidases CD39 and CD73, thereby inducing tolerogenic phenotype in the DC maturing quercetin-treated ,

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