polycyclic aromatic hydrocarbons (PAH), a group of persistent organic pollutants, associated with impaired immune function and low-grade inflammation in adults and children. However, the potential for causing a cytokine storm PAH associated with AHR (aryl hydrocarbon receptor) and NLRP3 (NLR family pyrin domain containing 3) in Human has been poorly studied. We aim to determine the relationship between exposure to PAH, AHR and NLRP3 expression, and cytokines associated with cytokine storm in healthy infants. demographic survey and a basic physical examination conducted on 248 preschoolers from electronic waste (e-waste) recycling area (Guiyu, n = 121) and the reference area (Haojiang, n = 127).
concentration of ten urinary PAH metabolites (OH-PAH) was measured. We also measure the level of expression of AHR and NLRP3 and seventeen levels of serum cytokines. several OH-PAH concentrations were significantly higher in the exposed group than in the reference group, especially 1-hydroxynaphthalene (1-OH-Nap) and 2-hydroxynaphthalene (2-OH-Nap). PAH exposure is closely related to the environment and hygiene habits of children. the level of expression of AHR and NLRP3 was significantly higher in the exposed group compared to the reference group. Similarly, serum IL -1β, IL -4, IL -5, IL -10, IL – 12p70 , IL -13, IL -17A, IL -18, < em> IL -22, IL -23, and IFN-γ were notably higher in children exposed e-waste than children of reference.
After adjusting for age, sex, BMI, family income, parental education, and traces of smoke exposure, we found that increased exposure to high PAH associated with AHR and NLRP3 expression and elevated IL -4, < em> IL -10, IL – 12p70 , IL -18, IL -22, IL -23, TNF-α, and IFN-γ levels. The relationship between PAH exposure and IL -1β, IL -18, IFN-γ and TNF-β are mediated by the expression of NLRP3, and the relationship between PAH exposure and IL -4, IL -10, IL – 12p70 , IL -22, IL -23, and TNF-α-mediated expression of AHR. Our findings indicate that the association between PAH exposure and can be mediated by cytokine storms and NLRP3 AHR expression among preschoolers.
Quercetin induces immunoregulatory phenotype in maturing human dendritic cells.
Aryl hydrocarbon receptor (AHR) is the environmental sensors and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and induction of tolerance to modulate immune cells. Such as dendritic cells (DC) express high levels of AHR, they efficiently induce immunomodulatory effects after exposure to AHR-activating compound derived from the environment or diet.
To gain new insights into the molecular target of AHR-activation following in Human monocyte-derived (mo) DC, we investigated whether natural or synthetic quercetin ligand AHR ligand 2,3,7,8-tetrachlorodibenzo p -dioxin (TCDD) to modulate the function of human moDCs regarding their ability to naive T cells prime or to migrate. Because only quercetin, but not TCDD, impaired T cell activation and migration of LPS-matured DC (LPS-DC), we analyzed the mode of action of quercetin on moDCs in more detail.
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx113230 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx104904 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101885 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101886 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101887 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx101888 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101889 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101890 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101891 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101892 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129396 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129503 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131946 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131947 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131948 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131949 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131950 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131951 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx128132 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx132312 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx036412-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx018000-100ug | Abbexa | 100 ug | EUR 460.8 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx001782 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx210848 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx211106 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173020 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173021 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173022 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173023 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173024 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177052 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177054 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177055 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx326469 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx300512 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx113230-100l | Abbexa | 100 µl | EUR 612.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx128132-100l | Abbexa | 100 µl | EUR 250 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx128132-1ml | Abbexa | 1 ml | EUR 675 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx128132-200l | Abbexa | 200 µl | EUR 312.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129396-100l | Abbexa | 100 µl | EUR 262.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129396-1ml | Abbexa | 1 ml | EUR 687.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129396-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129503-100l | Abbexa | 100 µl | EUR 262.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129503-1ml | Abbexa | 1 ml | EUR 687.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx129503-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173020-100l | Abbexa | 100 µl | EUR 812.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173020-1ml | Abbexa | 1 ml | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173020-200l | Abbexa | 200 µl | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173021-100l | Abbexa | 100 µl | EUR 812.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173021-1ml | Abbexa | 1 ml | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173021-200l | Abbexa | 200 µl | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173022-100l | Abbexa | 100 µl | EUR 850 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173022-1ml | Abbexa | 1 ml | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173022-200l | Abbexa | 200 µl | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173023-100l | Abbexa | 100 µl | EUR 850 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173023-1ml | Abbexa | 1 ml | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx173023-200l | Abbexa | 200 µl | Ask for price |
Interleukin 1 Alpha (IL1A) Antibody |
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abx210848-100l | Abbexa | 100 µl | EUR 350 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx210848-50l | Abbexa | 50 µl | EUR 250 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx211106-100l | Abbexa | 100 µl | EUR 350 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx211106-50l | Abbexa | 50 µl | EUR 250 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx177054-1096tests | Abbexa | 10 × 96 tests | EUR 812.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx177054-596tests | Abbexa | 5 × 96 tests | EUR 362.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx177054-96tests | Abbexa | 96 tests | EUR 287.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx036412-100g | Abbexa | 100 µg | EUR 337.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-400l | Abbexa | 400 µl | EUR 518.75 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx018000-1mg | Abbexa | 1 mg | EUR 300 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx300512-100g | Abbexa | 100 µg | EUR 362.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx300512-20g | Abbexa | 20 µg | EUR 162.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx300512-50g | Abbexa | 50 µg | EUR 250 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131946-100g | Abbexa | 100 µg | EUR 875 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131946-20g | Abbexa | 20 µg | EUR 375 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131946-5g | Abbexa | 5 µg | EUR 300 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131947-100g | Abbexa | 100 µg | EUR 712.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131947-20g | Abbexa | 20 µg | EUR 325 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131947-5g | Abbexa | 5 µg | EUR 262.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131948-100g | Abbexa | 100 µg | EUR 625 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131948-20g | Abbexa | 20 µg | EUR 300 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx131948-5g | Abbexa | 5 µg | EUR 237.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx131949-100g | Abbexa | 100 µg | EUR 875 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx131949-20g | Abbexa | 20 µg | EUR 375 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx131949-5g | Abbexa | 5 µg | EUR 300 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx131950-05mg | Abbexa | 0.5 mg | EUR 375 |
Interleukin 1 Alpha (IL1A) Antibody |
|||
abx131950-100g | Abbexa | 100 µg | EUR 300 |
Interleukin 1 Alpha (IL1A) Antibody |
|||
abx131951-100mg | Abbexa | 100 mg | EUR 812.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx131951-10mg | Abbexa | 10 mg | EUR 362.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx132312-01mg | Abbexa | 0.1 mg | EUR 262.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx326469-100g | Abbexa | 100 µg | EUR 250 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx326469-50g | Abbexa | 50 µg | EUR 187.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx001782-100l | Abbexa | 100 µl | EUR 400 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx001782-20l | Abbexa | 20 µl | EUR 175 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx001782-50l | Abbexa | 50 µl | EUR 275 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-100g | Abbexa | 100 µg | Ask for price |
Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-10g | Abbexa | 10 µg | EUR 362.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-200g | Abbexa | 200 µg | Ask for price |
Interleukin 1 Alpha (IL1a) Antibody |
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abx104904-100g | Abbexa | 100 µg | EUR 775 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx104904-20g | Abbexa | 20 µg | EUR 275 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx104904-50g | Abbexa | 50 µg | EUR 350 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101885-100l | Abbexa | 100 µl | EUR 287.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101885-1ml | Abbexa | 1 ml | EUR 825 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101885-200l | Abbexa | 200 µl | EUR 362.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101886-100l | Abbexa | 100 µl | EUR 212.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101886-1ml | Abbexa | 1 ml | EUR 475 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101886-200l | Abbexa | 200 µl | EUR 250 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101887-100l | Abbexa | 100 µl | EUR 250 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101887-1ml | Abbexa | 1 ml | EUR 675 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101887-200l | Abbexa | 200 µl | EUR 312.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx101888-100l | Abbexa | 100 µl | EUR 262.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx101888-1ml | Abbexa | 1 ml | EUR 725 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx101888-200l | Abbexa | 200 µl | EUR 337.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101889-100l | Abbexa | 100 µl | EUR 275 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101889-1ml | Abbexa | 1 ml | EUR 775 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101889-200l | Abbexa | 200 µl | EUR 350 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101890-100l | Abbexa | 100 µl | EUR 275 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101890-1ml | Abbexa | 1 ml | EUR 775 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101890-200l | Abbexa | 200 µl | EUR 350 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101891-100l | Abbexa | 100 µl | EUR 287.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101891-1ml | Abbexa | 1 ml | EUR 812.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101891-200l | Abbexa | 200 µl | EUR 362.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101892-100l | Abbexa | 100 µl | EUR 287.5 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101892-1ml | Abbexa | 1 ml | EUR 825 |
Interleukin 1 Alpha (IL1a) Antibody |
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abx101892-200l | Abbexa | 200 µl | EUR 362.5 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx109930-100l | Abbexa | 100 µl | EUR 162.5 |
Interleukin-1 Alpha (IL1A) Antibody |
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20-abx225241 | Abbexa |
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IL1A (untagged)-Human interleukin 1, alpha (IL1A) |
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SC324639 | Origene Technologies GmbH | 10 µg | Ask for price |
Interleukin 1 alpha (IL1a) (AP) |
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MBS6482358-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (AP) |
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MBS6482358-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 1 alpha (IL1a) (PE) |
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MBS6482368-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (PE) |
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MBS6482368-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 1 alpha (IL1a) (APC) |
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MBS6482359-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (APC) |
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MBS6482359-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 1 alpha (IL1a) (HRP) |
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MBS6482362-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (HRP) |
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MBS6482362-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 1 alpha (IL1a) (FITC) |
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MBS6482361-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (FITC) |
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MBS6482361-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Canine Interleukin-1 alpha (IL-1a) ELISA Kit, 96 tests, Quantitative |
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10475 | Alpha Diagnostics | 1 Kit | EUR 927.6 |
Active Interleukin 1 Alpha (IL1a) |
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APA071Cp61 | Cloud-Clone | 10ug | EUR 334 |
Active Interleukin 1 Alpha (IL1a) |
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APA071Eq61 | Cloud-Clone | 10ug | EUR 334 |
Active Interleukin 1 Alpha (IL1a) |
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APA071Hu01 | Cloud-Clone | 10ug | EUR 320 |
Active Interleukin 1 Alpha (IL1a) |
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4-APA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Active Interleukin 1 Alpha (IL1a) |
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APA071Hu02 | Cloud-Clone | 10ug | EUR 274 |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-100ug | Biomatik Corporation | 100ug | EUR 1022.9 |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-1mg | Biomatik Corporation | 1mg | EUR 4001.4 |
Active Interleukin 1 Alpha (IL1a) |
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RPU59102-50ug | Biomatik Corporation | 50ug | EUR 639.5 |
Active Interleukin 1 Alpha (IL1a) |
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RPU54864-100ug | Biomatik Corporation | 100ug | EUR 985.6 |
Active Interleukin 1 Alpha (IL1a) |
|||
RPU54864-1mg | Biomatik Corporation | 1mg | EUR 4368 |
Active Interleukin 1 Alpha (IL1a) |
|||
RPU54864-50ug | Biomatik Corporation | 50ug | EUR 792 |
Interleukin 1 alpha (IL1a) (Biotin) |
|||
MBS6482360-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 1 alpha (IL1a) (Biotin) |
|||
MBS6482360-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2122268-001mg | MyBiosource | 0.01mg | EUR 225 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2122268-005mg | MyBiosource | 0.05mg | EUR 450 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2122268-01mg | MyBiosource | 0.1mg | EUR 685 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2122268-02mg | MyBiosource | 0.2mg | EUR 845 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2122268-05mg | MyBiosource | 0.5mg | EUR 1630 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2097324-001mg | MyBiosource | 0.01mg | EUR 240 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2097324-005mg | MyBiosource | 0.05mg | EUR 515 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2097324-01mg | MyBiosource | 0.1mg | EUR 790 |
Active Interleukin 1 Alpha (IL1a) |
|||
MBS2097324-02mg | MyBiosource | 0.2mg | EUR 980 |
Here, we find the specific down-regulation of CD83 molecule immunomodulators through direct binding of AHR is activated for CD83 promoter. In addition, treatment of LPS-DC with quercetin resulted in reduced production of pro-inflammatory cytokines IL – 12p70 and the increased expression of molecules immunoregulatory protein adapter is disabled (Dab) 2, immunoglobulin-like transcript ( IL T) -3, IL T4, IL T5 and ectonucleotidases CD39 and CD73, thereby inducing tolerogenic phenotype in the DC maturing quercetin-treated ,