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Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients

Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients
Posted by Curtis

systemic inflammation, endothelial dysfunction and coagulopathy has high clinical relevance in the management of the living with HIV (PLHIV), and even more in patients coinfected with hepatitis C virus (HCV). It has been suggested a significant impact of HCV on these conditions. However, HCV can be eradicated in most patients with new direct-acting antiviral (DaaS) therapy. We have analyzed the effect of HCV on systemic inflammation, endothelial activation and coagulopathy in people living with HIV and its evolution after the eradication of HCV with Daas. Twenty-five HIV / HCV coinfection (/ HIV HCV group), 25 HIV monoinfected (HIV group) and 20 healthy controls (HC) were included in this study.

All patients were on antiretroviral therapy and HIV suppressed. Level fourteen signs of systemic inflammation, endothelial activation and coagulopathy ( IL -1ß, IL -6, IL – 12p70 , IL -8, TNF, D-dimer, eotaxin, IL -18, IP-10, monocyte chemotactic protein-1 (MCP-1), plasminogen activator inhibitor -1 (PAI-1), TNF receptor 1 (TNFR1), vascular cell adhesion molecule 1 (VCAM-1) and an adhesion molecule 1 (ICAM-1)) measured in the plasma at the beginning and after the eradication of HCV-mediated Daas. non-parametric tests used to establish the difference between / intra-group. At the beginning, / HIV HCV group showed increased levels of IL -18 ( p = 0.028), IP-10 ( p <0.0001) , VCAM-1 ( p <0.0001) and ICAM-1 ( p = 0.045), compared to HC and HIV groups, with the highest levels to IL 18 and IP10 observed in patients with HIV / HCV with increased liver stiffness (≥7.1 kPa).

HCV eradication Daas based therapy restored some but not all parameters evaluated. VCAM-1 remained significantly increased compared to HC ( p = 0.001), regardless of the level of the basal liver stiffness in a group of HIV / HCV, and IP-10 still increased significantly only in HIV / HCV group, with an increase in the basal level of liver stiffness compared to HC and HIV groups ( p = 0.006 and p = 0.049, respectively). These data indicate that Daas therapy in patients with HIV / HCV coinfection and HCV eradication does not always lead to the normalization of systemic inflammation and endothelial dysfunction conditions, especially in cases with an increase in liver stiffness.

Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients
Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients

Notch-mediated generation of monocyte-derived Langerhans cells: phenotype and function

Langerhans cells (LC) in the skin is the first line of defense against pathogens but also plays an important role in skin homeostasis. their exclusive expression of C-type lectin receptor Langerin / CD207 makes them prime candidates for immunotherapy. To test the vaccine, an easily accessible cell platform would be desirable as an alternative to time-consuming purification LC of Human the skin.

Here we have a model like this and show that monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF), transforming growth factor (TGF) -β1 and Notch ligand Delta-like 4 (DLL4) within 3 days differentiate into CD1a + Langerin + cells containing Birbeck granules. RNA-sequencing (RNA-seq) monocyte-derived LC’s (moLCs) confirmed the expression of genes related molecules LC, pattern recognition receptors and enhanced expression of antigen-presenting machinery.

Equine Interleukin 10 (IL10) ELISA Kit

RD-IL10-Eq-48Tests 48 Tests
EUR 505

Equine Interleukin 10 (IL10) ELISA Kit

RD-IL10-Eq-96Tests 96 Tests
EUR 700

Goat Interleukin 10 (IL10) ELISA Kit

RD-IL10-g-48Tests 48 Tests
EUR 505

Goat Interleukin 10 (IL10) ELISA Kit

RD-IL10-g-96Tests 96 Tests
EUR 700

Human Interleukin 10 (IL10) ELISA Kit

RD-IL10-Hu-48Tests 48 Tests
EUR 333

Human Interleukin 10 (IL10) ELISA Kit

RD-IL10-Hu-96Tests 96 Tests
EUR 454

Mouse Interleukin 10 (IL10) ELISA Kit

RD-IL10-Mu-48Tests 48 Tests
EUR 341

Mouse Interleukin 10 (IL10) ELISA Kit

RD-IL10-Mu-96Tests 96 Tests
EUR 466

Porcine Interleukin 10 (IL10) ELISA Kit

RD-IL10-p-48Tests 48 Tests
EUR 494

Porcine Interleukin 10 (IL10) ELISA Kit

RD-IL10-p-96Tests 96 Tests
EUR 684

Rat Interleukin 10 (IL10) ELISA Kit

RD-IL10-Ra-48Tests 48 Tests
EUR 450

Rat Interleukin 10 (IL10) ELISA Kit

RD-IL10-Ra-96Tests 96 Tests
EUR 622

Rabbit Interleukin 10 (IL10) ELISA Kit

RD-IL10-Rb-48Tests 48 Tests
EUR 450

Rabbit Interleukin 10 (IL10) ELISA Kit

RD-IL10-Rb-96Tests 96 Tests
EUR 622

Bovine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-b-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-b-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-c-48T 48T
EUR 474
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-c-96T 96T
EUR 614
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Ch-48T 48T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Ch-96T 96T
EUR 587
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Eq-48T 48T
EUR 503
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Eq-96T 96T
EUR 654
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 10 (IL10) ELISA Kit

DLR-IL10-g-48T 48T
EUR 503
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Goat Interleukin 10 (IL10) ELISA Kit

DLR-IL10-g-96T 96T
EUR 654
Description: A sandwich quantitative ELISA assay kit for detection of Goat Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Hu-48T 48T
EUR 350
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Hu-96T 96T
EUR 444
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Mu-48T 48T
EUR 357
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Mu-96T 96T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-p-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 10 (IL10) ELISA Kit

DLR-IL10-p-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Ra-48T 48T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Ra-96T 96T
EUR 587
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Rb-48T 48T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Rb-96T 96T
EUR 587
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-b-48Tests 48 Tests
EUR 516

Bovine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-b-96Tests 96 Tests
EUR 716

Canine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-c-48Tests 48 Tests
EUR 493

Canine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-c-96Tests 96 Tests
EUR 683

Chicken Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Ch-48Tests 48 Tests
EUR 470

Chicken Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Ch-96Tests 96 Tests
EUR 651

Equine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Eq-48Tests 48 Tests
EUR 528

Equine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Eq-96Tests 96 Tests
EUR 733

Goat Interleukin 10 (IL10) ELISA Kit

RDR-IL10-g-48Tests 48 Tests
EUR 528

Goat Interleukin 10 (IL10) ELISA Kit

RDR-IL10-g-96Tests 96 Tests
EUR 733

Human Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Hu-48Tests 48 Tests
EUR 347

Human Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Hu-96Tests 96 Tests
EUR 474

Mouse Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Mu-48Tests 48 Tests
EUR 356

Mouse Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Mu-96Tests 96 Tests
EUR 487

Porcine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-p-48Tests 48 Tests
EUR 516

Porcine Interleukin 10 (IL10) ELISA Kit

RDR-IL10-p-96Tests 96 Tests
EUR 716

Rat Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Ra-48Tests 48 Tests
EUR 470

Rat Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Ra-96Tests 96 Tests
EUR 651

Rabbit Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Rb-48Tests 48 Tests
EUR 470

Rabbit Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Rb-96Tests 96 Tests
EUR 651

Guinea pig Interleukin 10 (IL10) ELISA Kit

RD-IL10-Gu-48Tests 48 Tests
EUR 472

Guinea pig Interleukin 10 (IL10) ELISA Kit

RD-IL10-Gu-96Tests 96 Tests
EUR 653

Guinea pig Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Gu-48T 48T
EUR 474
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 10 (IL10) ELISA Kit

DLR-IL10-Gu-96T 96T
EUR 614
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Gu-48Tests 48 Tests
EUR 493

Guinea pig Interleukin 10 (IL10) ELISA Kit

RDR-IL10-Gu-96Tests 96 Tests
EUR 683

Interleukin 10 (IL10) Antibody

20-abx130143
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx130919
  • EUR 328.00
  • EUR 133.00
  • EUR 899.00
  • EUR 453.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx130920
  • EUR 328.00
  • EUR 133.00
  • EUR 899.00
  • EUR 453.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx130921
  • EUR 467.00
  • EUR 133.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

abx117238-100ug 100 ug
EUR 467

Interleukin 10 (IL10) Antibody

20-abx109331
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx109411
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx323722
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx001783
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 10 (IL10) Antibody

20-abx104900
  • EUR 314.00
  • EUR 133.00
  • EUR 829.00
  • EUR 439.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx104934
  • EUR 453.00
  • EUR 133.00
  • EUR 1316.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx101173
  • EUR 328.00
  • EUR 133.00
  • EUR 899.00
  • EUR 453.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx101174
  • EUR 328.00
  • EUR 133.00
  • EUR 899.00
  • EUR 453.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx101175
  • EUR 328.00
  • EUR 133.00
  • EUR 913.00
  • EUR 467.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx101176
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

abx034229-400ul 400 ul
EUR 523

Interleukin 10 (IL10) Antibody

abx034229-80l 80 µl
EUR 286

Interleukin 10 (IL10) Antibody

20-abx131817
  • EUR 356.00
  • EUR 926.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx131818
  • EUR 328.00
  • EUR 843.00
  • EUR 439.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx131819
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx131820
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx132171
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx137087
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg

Interleukin 10 (IL10) Antibody

20-abx137098
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg

Interleukin 10 (IL10) Antibody

20-abx007496
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Interleukin 10 (IL10) Antibody

abx011006-100ul 100 ul
EUR 411

Interleukin 10 (IL10) Antibody

20-abx177073
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug

Interleukin 10 (IL10) Antibody

20-abx177074
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx177075
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Interleukin 10 (IL10) Antibody

20-abx177076
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx177077
  • EUR 1316.00
  • EUR 634.00
  • 1 mg
  • 200 ug

Interleukin 10 (IL10) Antibody

20-abx177078
  • EUR 1372.00
  • EUR 648.00
  • 1 mg
  • 200 ug

Interleukin 10 (IL10) Antibody

20-abx173049
  • EUR 328.00
  • EUR 815.00
  • EUR 425.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 10 (IL10) Antibody

20-abx173050
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug

At the protein level, moLCs showed low expression costimulatory molecule but an expression that stands out from the type C lectin receptors. MoLCs can mature, secrete IL – 12p70 and TNF-α and stimulates proliferation and cytokine production in allogeneic CD4 + and CD8 + < / sup> T cell vaccine in terms of testing, a Langerin glycomimetic recently marked ligand conjugate liposomes showed specific and rapid internalization into moLCs. Therefore, these short-term moLCs vitro produced an interesting tool to screen LC-based vaccines in the future.

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