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Analysis of the Role of Palmitoleic Acid in Acute Anterior Uveitis

Analysis of the Role of Palmitoleic Acid in Acute Anterior Uveitis
Posted by Curtis

Objective: To study the role of palmitoleic acid (PA) in the pathogenesis of acute anterior uveitis (AAU).
Methods: The levels of PA in the stools of patients AAU measured by gas chromatography coupled with mass spectrometry (GC-MS) and compared with samples obtained from healthy individuals. Enzyme Linked Immunosorbent Assay (ELISA) and flow cytometry (FCM) was used to assess the effects of PA on dendritic cells (DC) and CD4 + T cells obtained from mice, AAU patients and healthy individuals. C57BL / 6 mice were fed with PA or vehicle and experimental autoimmune uveitis (EAU) was induced by human retina IRBP651-670 peptides.

Disease severity was evaluated with clinical manifestations of EAU and histology. Spleen cell differentiation of type 1 T helper (Th1) and Th17 cells was evaluated by FCM. tandem mass tags (TMT) based proteomics analysis was used to identify proteins expressed differently following the incubation of DC with the PA.


Results: The concentration of droppings from AAU PA increased in patients compared with healthy people. In vitro, PA promoted apoptosis of DC and inhibit the secretion of TNF-α from mouse cells bone marrow-derived dendritic (BMDCs) as well as DC from AAU patients and healthy individuals. Just downhill DC surface marker expression and IL-12p70 secretion in BMDCs and healthy individuals but not in DC DC AAU patients. PA-treated BMDCs inhibited Th cell differentiation from naive mice cells CD4 + T cells and IL-17 and IFN-γ secretion in co-culture supernatant. PA also inhibit Th cell differentiation and secretion of IFN-γ and IL-17 in CD4 + T cells from mice, AAU patients and healthy individuals. In vivo, PA-treated EAU mice showed clinical and histopathological manifestations of intraocular lighter than the control group.

PA eat spleen inhibits Th17 cell differentiation, whereas Th1 cells are not affected. Up to 30 upregulated and downregulated 77 proteins were identified when comparing the PA-treated DC with control.
Conclusions: An increased expression of PA feces observed in patients AAU. PA proved to have immunoregulatory effects on DC cells and CD4 + T and attenuated the severity of the disease in EAU mice.

Analysis of the Role of Palmitoleic Acid in Acute Anterior Uveitis
Analysis of the Role of Palmitoleic Acid in Acute Anterior Uveitis

Accelerated biological aging, chronic stress, and Risk of Sepsis and Organ Failure Following Trauma.

chronic stress and accelerated aging has been shown to have an impact on the inflammatory response and related outcomes such as sepsis and organ failure, but data is lacking in the literature of trauma. The purpose of this study was to investigate the potential link between stress and outcome pretrauma posttrauma. the hypothesis is that chronic stress pretrauma accelerate aging, which increases susceptibility to posttrauma sepsis and organ failure. In the prospective, this correlational study, chronic stress and premature aging biological compared with systemic inflammatory response syndrome, sepsis and organ failure in trauma patients aged 18-44 years.

The results support the hypothesis with a significant overall association between susceptibility to sepsis and premature biological aging (n = 142). There was also a significant negative association between cytokine levels mean and chronic stress. The strongest association was found between average interleukin-1β ( IL -1β) and Human telomerase reverse transcriptase (hTERT), r (101) = -0.28), p = , 004. significant negative association was found between the levels of cytokines mean, IL – 12p70 , r (108) = -0.20, p = 0.034; and tumor necrosis factor-α (TNF-α), r (108) = -0.20, p = 0.033, and positive life events through behavioral measure chronic stress.

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-48Tests 48 Tests
EUR 302

Human Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Hu-96Tests 96 Tests
EUR 411

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-48Tests 48 Tests
EUR 341

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Mu-96Tests 96 Tests
EUR 466

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-48Tests 48 Tests
EUR 494

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-p-96Tests 96 Tests
EUR 684

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-48Tests 48 Tests
EUR 358

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Ra-96Tests 96 Tests
EUR 490

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-48Tests 48 Tests
EUR 358

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Rb-96Tests 96 Tests
EUR 490

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-b-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-b-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-c-48T 48T
EUR 388
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-c-96T 96T
EUR 496
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ch-48T 48T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ch-96T 96T
EUR 587
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Eq-48T 48T
EUR 503
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Eq-96T 96T
EUR 654
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-48T 48T
EUR 323
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Hu-96T 96T
EUR 407
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-48T 48T
EUR 357
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Mu-96T 96T
EUR 454
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-48T 48T
EUR 493
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-p-96T 96T
EUR 641
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Ra-96T 96T
EUR 475
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-48T 48T
EUR 372
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Rb-96T 96T
EUR 475
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-48T 48T
EUR 576
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Si-96T 96T
EUR 755
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-48Tests 48 Tests
EUR 516

Bovine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-b-96Tests 96 Tests
EUR 716

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-48Tests 48 Tests
EUR 391

Canine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-c-96Tests 96 Tests
EUR 538

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-48Tests 48 Tests
EUR 470

Chicken Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ch-96Tests 96 Tests
EUR 651

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-48Tests 48 Tests
EUR 528

Equine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Eq-96Tests 96 Tests
EUR 733

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-48Tests 48 Tests
EUR 315

Human Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Hu-96Tests 96 Tests
EUR 429

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-48Tests 48 Tests
EUR 356

Mouse Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Mu-96Tests 96 Tests
EUR 487

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-48Tests 48 Tests
EUR 516

Porcine Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-p-96Tests 96 Tests
EUR 716

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-48Tests 48 Tests
EUR 374

Rat Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Ra-96Tests 96 Tests
EUR 512

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-48Tests 48 Tests
EUR 374

Rabbit Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Rb-96Tests 96 Tests
EUR 512

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-48Tests 48 Tests
EUR 614

Monkey Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Si-96Tests 96 Tests
EUR 856

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-48Tests 48 Tests
EUR 375

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RD-IL1b-Gu-96Tests 96 Tests
EUR 515

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-48T 48T
EUR 388
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

DLR-IL1b-Gu-96T 96T
EUR 496
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 1 Beta (IL1b) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-48Tests 48 Tests
EUR 391

Guinea pig Interleukin 1 Beta (IL1b) ELISA Kit

RDR-IL1b-Gu-96Tests 96 Tests
EUR 538

Anti-IL1 beta/Il1b Antibody

A00101-1 100ug/vial
EUR 294

Interleukin 1 Beta (IL1B) Antibody

20-abx125995
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx125996
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 1 Beta (IL1b) Antibody

20-abx128522
  • EUR 314.00
  • EUR 133.00
  • EUR 815.00
  • EUR 425.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx129733
  • EUR 328.00
  • EUR 133.00
  • EUR 913.00
  • EUR 467.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx130423
  • EUR 467.00
  • EUR 133.00
  • EUR 1372.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109931
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx109932
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110440
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx110441
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx113231
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Interleukin 1 Beta (IL1b) Antibody

20-abx104871
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101763
  • EUR 328.00
  • EUR 133.00
  • EUR 913.00
  • EUR 467.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx101764
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101765
  • EUR 342.00
  • EUR 133.00
  • EUR 954.00
  • EUR 481.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101766
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101767
  • EUR 356.00
  • EUR 133.00
  • EUR 996.00
  • EUR 495.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx101768
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101769
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx101770
  • EUR 453.00
  • EUR 133.00
  • EUR 1316.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

abx037983-100ug 100 ug
EUR 391

Interleukin 1 Beta (IL1b) Antibody

20-abx131952
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131953
  • EUR 356.00
  • EUR 926.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131954
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131955
  • EUR 356.00
  • EUR 913.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx131956
  • EUR 328.00
  • EUR 843.00
  • EUR 439.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx131957
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx131958
  • EUR 356.00
  • EUR 913.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Interleukin 1 Beta (IL1b) Antibody

20-abx132185
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Interleukin 1 Beta (IL1B) Antibody

20-abx141200
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx136150
  • EUR 495.00
  • EUR 356.00
  • 100 ul
  • 50 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx137010
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx137171
  • EUR 425.00
  • EUR 648.00
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx137172
  • EUR 425.00
  • EUR 648.00
  • 0.5 mg
  • 1 mg

Interleukin 1 Beta (IL1B) Antibody

20-abx001029
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Interleukin 1 Beta (IL1B) Antibody

20-abx009120
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

The results can help identify individuals at increased risk for poor outcomes of trauma and inform interventions that can reduce the risk of sepsis and organ failure.

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