Recently there was a paradigm shift in the field of Dendritic immunotherapy (DC) Dendritic, where several clinical studies have confirmed feasibility and excellence using DCS originating from human blood isolated directly above distinguished vitro. There are two main DC sets found in the blood; Plasmacytoid DCS (PDC) and Myeloid DCS (MDCs), and both have been clinically tested. CD1C + MDC is a cell that presents a highly efficient antigen that has the ability to issue IL-12P70, while PDC is the cells that are excluded professionally ifn-α which is proven to induce default immune response in melanoma patients.
Therefore, combining MDC and PDCs poses as an attractive multi-function vaccine approach. However, the type of IFNS has been reported to inhibit the production of IL-12P70 and MDC-induced MDC cell activation. In this study, we investigate the effect of IFN-α in the maturation and MDC function. We show that the two IFN-α PDC is recuminated and activated greatly increases MDC maturation and increases IL-12P70 production. MDC and PDCs that are cultured together also have beneficial effects on NK activation and cells and also increases IFN-γ production with allogeneic t cells. Conversely, the existence of type I IFN reduces proliferative cell response. The presence is only a small part of PDC active enough for this effect and the ratio needed between the set of insecure parts. Taken together, these results support the use of MDC and PDC combined into one immunotherapy vaccine with a broad immunostimulator feature.
The intraperitoneal government of Chimeric Immunogen (ROP) novel raises IFN-γ and <em> il </ em> 12p70 </ em> protective immune response in Balb / C mice against Brucella virulent.
Immunologically active chimeric protein recording consisting of the OMP19 and P39 domains of B. abortion (ROP), purified in conditions of denaturation on expression in E. coli BL21 (DE3) and repair with dynamic forms. Imuno Protective ROP properties are evaluated by challenging balb / c intraperiterally (IP) with infective species Brucella in the absence or presence of adjuvants, such as aluminum hydroxide gel (AL), or complete freund (FCA) / Adjuvant Freund (IFA) , Strangely, after the second decline, mice received ROP per se found immunogenic in terms of IgG response with the dominant expression of IGG2A and IFN-γ which was significant with LFus T cells, indicating that ROP was a strong induction of anti-brucella immunity.
The produced anti-rop antibodies recognize the original OMP19 and P39 among Brucella species and a single band and a single band against Chimera in immunoblot. Enhanced antibody response and proportional to the combination of IgG isotypes that vary in mice are prepared and driven by ROP on adjuvant. However, ROP + FCA / IFA formulation was found most effectively in the lymphocyte test remembering significant induction (P <0.001) the proliferation index (PI) and the increase in cytokines combined (IFN-γ, IL-2 and IL -12P70) of ROP + AL In response to ROP recounts.
Furthermore, in vitro defensive tests revealed that compared to anti-rop antisera, anti-sera polyclonal of ROP + Adjuvants showed an increase in RAW264.7 cells on virulent challenges by B. Melitensis 16M and B. abortion 544. In addition, compared to Sham Group , Enumeration of CFU Brucella after a challenge with the species above shows a significant reduction of bacteria (P <0.01) (CFU log) in the macrophage cell line and vaccinated rat organs. Overall, a relatively higher reduction and was more quickly noticed on vaccinated mice with a similar number of pure antigens in the Freund Adjuvant. The ability to induce immune protection directed by the absence of adjuvant support, crashing ROP as a reasonable participant to develop a chimeric-based subunit vaccine against Brucella.
Brucella abortion strains 19 invades, survive, and activate human dendritic cells, and induce the secretion of <em> il </ em> 12p70 </ em> but not <el> – 23.
Vector bacteria has been proposed as a new vaccine strategy to encourage strong cellular immunity. Entitulated Brucella strains consist of a promising vector candidate because they have the potential to induce the response of immune mediated CD4 (+) and CD8 (+) which are strong with the absence of excessive inflammation such as observed with other gram-negative bacteria. However, some strains of Brucella disturb the maturation of dendritic cells (DCS), which are important for the priming of antigen specific T cells. In this study, we investigated DC interactions which were derived from the human monocyte smoothly weakening B. Abotor strain 19, which had previously been employed successfully to vaccinate livestock.
![Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and <em>IL</em>-<em>12p70</em> production and mediate elevated effector functions in innate and adaptive immune cells.](https://il-12p70.com/wp-content/uploads/2020/12/photo_2020-11-19_01-10-30-146x300.jpg)
We first saw the potential of S19 to inhibit the maturation of DC caused by cytokines; However, infected cells are expressed by CD25, CD40, CD80, and CD86 to the extent that are comparable as DC that is not infected and mature. Furthermore, S19 activates DCS in the absence of exogenous stimuli, increases HLA-ABC and HLA-DR expression, and is able to survive intracellularly without causing cytotoxicity. Thus, DCS provides a cellular niche for Brucella which survives in vivo as a permanent source of antigen. S19-infected DCS produces IL-12 / 23P40, IL-12P70, and IL-10, but not IL-23. While hot bacteria also activate DCS, the soluble mediator is not involved in the activation of S19 induced human DC. HEK 293 Transfectants revealed cellular activation by S19 mainly through receptor involvement such as toll (TLR) 2. Thus, as an immunological prerequisite for the efficacy of vaccines, B. S19 abortion has the potential to infect and potentially activate (most likely through TLR2) human DCS to produce cytokines that promote TH1.
Locus new vulnerability in <em> il </ em> Region 12b is associated with the pathophysiology of Takayasu arteritis to <em> il </ em> -12p40 and <em> il </ em> <br70 </ em> production.
A previous study revealed the relationship between the vulnerability to Takayasu arteritis (no) and one nucleotide polymorphism (SNP) RS6871626 located in IL12B, which encodes Interleukin (IL) -12P40, general components of IL-12P70 and IL-23. We investigate this cytokine expression in patients with no, emphasizing them into them with or without risk of alleles at SNP RS6871626.
The Level of Plasma IL-12P40, IL-12P70, and IL-23 were quantified in 44 patients with no and 19 healthy controls (HCS) by testing enzyme immunosorbents. Monocytes are obtained from 20 patients with no and 14 HCS, treated with interferon-γ (IFN-γ) and lipopolysaccharide, and then the cytokine supernatis is quantified. In addition, IFN-γ + or IL-17A + cell ratios to CD4 + cells are measured by the analysis of cytometric flow of peripheral mononuclear blood cells.
Rabbit anti-Human IL-12P70 mAb(CAP) |
RMK0070 |
Abclonal |
200μg |
EUR 1689.77 |
Rabbit anti-Human IL-12p70 mAb(DET) |
RMK0090 |
Abclonal |
500μg |
EUR 357.79 |
human anti-human IL-12/IL-23 p40 mAb(3H2) |
E4A09D33-3H2 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-12/IL-23 p40 mAb(5N9) |
E4A09D33-5N9 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-12/IL-23 p40 mAb(1G11) |
E4A09D33-1G11 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-23 p19 mAb(G71) |
E4A09D34-G71 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Mouse anti Human IL6/IL-6 Antibody, Mouse MAb |
MBS2543362-006mL |
MyBiosource |
0.06mL |
EUR 250 |
Mouse anti Human IL6/IL-6 Antibody, Mouse MAb |
MBS2543362-012mL |
MyBiosource |
0.12mL |
EUR 370 |
Mouse anti Human IL6/IL-6 Antibody, Mouse MAb |
MBS2543362-02mL |
MyBiosource |
0.2mL |
EUR 550 |
Human P16 Mouse mAb |
E2220148 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Human P16 Mouse mAb |
MBS8538358-01mL |
MyBiosource |
0.1mL |
EUR 305 |
Human P16 Mouse mAb |
MBS8538358-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Human P16 Mouse mAb |
MBS8538358-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Human P16 Mouse mAb |
MBS8538358-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Human P16 Mouse mAb |
MBS8538358-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
mAb mouse anti-human IL-2 |
CT252 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-4 |
CT253 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-5 |
CT255 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-8 |
CT264 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-6 |
CT272 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-13 |
CT227 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-10 |
CT254 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-10 |
CT256 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-1β |
CT269 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-31 |
CT686 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-31 |
CT687 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-33 |
CT688 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-33 |
CT689 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-17A |
CT291 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-17A |
CT292 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-17F |
CT293 |
U-CyTech |
0.5 mg |
EUR 312 |
Anti-SND1/P100 Mouse mAb |
MBS475825-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-SND1/P100 Mouse mAb |
MBS475825-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Human IL-12p70 |
MBS692496-0002mg |
MyBiosource |
0.002mg |
EUR 300 |
Human IL-12p70 |
MBS692496-001mg |
MyBiosource |
0.01mg |
EUR 450 |
Human IL-12p70 |
MBS692496-5x001mg |
MyBiosource |
5x0.01mg |
EUR 1725 |
mAb mouse anti-human IL-23p19 |
CT284 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-human IL-23p19 |
CT285 |
U-CyTech |
0.5 mg |
EUR 312 |
Anti-AMACR/P504S Mouse mAb |
E2250016 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-AMACR/P504S Mouse mAb |
MBS8533250-01mL |
MyBiosource |
0.1mL |
EUR 305 |
Anti-AMACR/P504S Mouse mAb |
MBS8533250-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Anti-AMACR/P504S Mouse mAb |
MBS8533250-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Anti-AMACR/P504S Mouse mAb |
MBS8533250-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Anti-AMACR/P504S Mouse mAb |
MBS8533250-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Anti-AMACR/P504S Mouse mAb |
MBS477224-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-AMACR/P504S Mouse mAb |
MBS477224-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1530 |
Anti-NFkB p105/p50 Mouse mAb |
MBS475606-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-NFkB p105/p50 Mouse mAb |
MBS475606-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1530 |
P16 (Mouse and Human) Mouse mAb |
E2220140 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
P16 (Mouse and Human) Mouse mAb |
E2220141 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
P16 (Mouse and Human) Mouse mAb |
MBS8538350-01mL |
MyBiosource |
0.1mL |
EUR 305 |
P16 (Mouse and Human) Mouse mAb |
MBS8538350-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538350-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538350-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538350-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538351-01mL |
MyBiosource |
0.1mL |
EUR 305 |
P16 (Mouse and Human) Mouse mAb |
MBS8538351-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538351-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538351-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
P16 (Mouse and Human) Mouse mAb |
MBS8538351-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
mouse anti-human IL-2 mAb |
E409C12-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-4 mAb |
E409C13-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-5 mAb |
E409C14-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-8 mAb |
E409C16-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-5 mAb |
E4A09D05-m |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Mouse anti-Human IL-2 mAb |
MBS8576801-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-2 mAb |
MBS8576801-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-2 mAb |
MBS8576801-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-2 mAb |
MBS8576801-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-2 mAb |
MBS8576801-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-Human IL-4 mAb |
MBS8576803-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-4 mAb |
MBS8576803-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-4 mAb |
MBS8576803-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-4 mAb |
MBS8576803-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-4 mAb |
MBS8576803-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-Human IL-5 mAb |
MBS8576805-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-5 mAb |
MBS8576805-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-5 mAb |
MBS8576805-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-5 mAb |
MBS8576805-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-5 mAb |
MBS8576805-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-Human IL-8 mAb |
MBS8576809-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-8 mAb |
MBS8576809-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-8 mAb |
MBS8576809-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-8 mAb |
MBS8576809-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-8 mAb |
MBS8576809-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Anti-human IL-1beta mAb (7P10), biotin |
3416-6-1000 |
Mabtech AB |
1 mg |
EUR 1044.75 |
Anti-human IL-1beta mAb (7P10), biotin |
3416-6-250 |
Mabtech AB |
250 µg |
EUR 283.5 |
mouse anti-human IL-1β mAb |
E409C11-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-10 mAb |
E409C17-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
Mouse anti-Human IL-10 mAb |
MBS8576811-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-10 mAb |
MBS8576811-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-10 mAb |
MBS8576811-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-10 mAb |
MBS8576811-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-10 mAb |
MBS8576811-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
mouse anti-human IL-17A mAb |
E409C18-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
Mouse anti-Human IL-17A mAb |
MBS8576812-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-17A mAb |
MBS8576812-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-17A mAb |
MBS8576812-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-17A mAb |
MBS8576812-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-17A mAb |
MBS8576812-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-Human IL-1beta mAb |
MBS8576799-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-1beta mAb |
MBS8576799-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-1beta mAb |
MBS8576799-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-1beta mAb |
MBS8576799-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-1beta mAb |
MBS8576799-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Anti-HIV p24 Mouse mAb |
MBS477400-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-HIV p24 Mouse mAb |
MBS477400-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-Cytochrome P450 17A1 Mouse mAb |
E2200758 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-Cytochrome P450 17A1 Mouse mAb |
MBS475082-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-Cytochrome P450 17A1 Mouse mAb |
MBS475082-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-PI3 Kinase p110gamma Mouse mAb |
MBS476593-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-PI3 Kinase p110gamma Mouse mAb |
MBS476593-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-NFkB p65 Mouse mAb |
E2250021 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-NFkB p65 Mouse mAb |
E2250060 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-NFkB p65 Mouse mAb |
MBS8533255-01mL |
MyBiosource |
0.1mL |
EUR 305 |
Anti-NFkB p65 Mouse mAb |
MBS8533255-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533255-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533255-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533255-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533294-01mL |
MyBiosource |
0.1mL |
EUR 305 |
Anti-NFkB p65 Mouse mAb |
MBS8533294-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533294-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533294-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS8533294-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Anti-NFkB p65 Mouse mAb |
MBS475611-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-NFkB p65 Mouse mAb |
MBS475611-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1530 |
Anti-NFkB p65 Mouse mAb |
MBS477226-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-NFkB p65 Mouse mAb |
MBS477226-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-NFkB p65 Mouse mAb |
MBS477251-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-NFkB p65 Mouse mAb |
MBS477251-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-SQSTM1/p62 Mouse mAb |
MBS476956-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-SQSTM1/p62 Mouse mAb |
MBS476956-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1530 |
mouse anti-human IL-4 mAb(08) |
E4A09D04-m-08 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
mouse anti-human IL-4 mAb(10) |
E4A09D04-m-10 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
mouse anti-human IL-6 mAb(L7) |
E4A09D06-L7 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
mouse anti-human IL-6 mAb(R5) |
E4A09D06-R5 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Anti-S100A10/P11 Mouse mAb |
MBS475731-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-S100A10/P11 Mouse mAb |
MBS475731-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1530 |
mouse anti-human IL-8 mAb(Q10) |
E4A09D07-Q10 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
mouse anti-human IL-8 mAb(Q36) |
E4A09D07-Q36 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
mouse anti-human IL-6 mAb(1M4C) |
E409C15-m4C100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-human IL-6 mAb(2M4Z) |
E409C15-m4Z100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
Mouse anti-Human IL-6 mAb (1M4C) |
MBS8576806-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-6 mAb (1M4C) |
MBS8576806-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-6 mAb (1M4C) |
MBS8576806-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-6 mAb (1M4C) |
MBS8576806-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-6 mAb (1M4C) |
MBS8576806-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-Human IL-6 mAb (2M4Z) |
MBS8576807-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-Human IL-6 mAb (2M4Z) |
MBS8576807-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-Human IL-6 mAb (2M4Z) |
MBS8576807-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-Human IL-6 mAb (2M4Z) |
MBS8576807-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-Human IL-6 mAb (2M4Z) |
MBS8576807-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
mAb mouse anti-rat IL-4 |
CT028 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-rat IL-4 |
CT029 |
U-CyTech |
0.5 mg |
EUR 312 |
Mouse IL-12p70 ELISA Kit |
E16ME0013 |
EnoGene |
96T |
EUR 833.33 |
Mouse IL-12p70 ELISA KTI |
E16ME0013-048 |
EnoGene |
48 wells |
EUR 295 |
Mouse IL-12p70 ELISA KTI |
E16ME0013-096 |
EnoGene |
96 wells |
EUR 395 |
Mouse IL-12p70 ELISA kit |
E22-MC006.48 |
EnoGene |
48T |
EUR 295 |
Mouse IL-12p70 ELISA kit |
E22-MC006.96 |
EnoGene |
96T |
EUR 395 |
Mouse IL-12p70 ELISA Kit |
E28L0063 |
EnoGene |
96T |
EUR 666.67 |
Mouse IL-12p70 ELISA Kit |
MBS8579363-48Tests |
MyBiosource |
48Tests |
EUR 390 |
Mouse IL-12p70 ELISA Kit |
MBS8579363-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2275 |
Mouse IL-12p70 ELISA Kit |
MBS8579363-96Tests |
MyBiosource |
96Tests |
EUR 495 |
Mouse IL-12p70 ELISA KIT |
MBS8506065-48Wells |
MyBiosource |
48Wells |
EUR 390 |
Mouse IL-12p70 ELISA KIT |
MBS8506065-5x96Wells |
MyBiosource |
5x96Wells |
EUR 2275 |
Mouse IL-12p70 ELISA KIT |
MBS8506065-96Wells |
MyBiosource |
96Wells |
EUR 495 |
Rabbit anti-human IL-12 p40 mAb |
RM17977 |
Abclonal |
100μg |
EUR 350.71 |
Rabbit anti-human IL-12 p40 mAb |
RM17978 |
Abclonal |
500μg |
EUR 350.71 |
Rabbit anti-human IL-12 p40 mAb |
RM17979 |
Abclonal |
200μg |
EUR 974.19 |
mAb mouse anti-monkey IL-4 |
CT103 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-monkey IL-6 |
CT104 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-monkey IL-5 |
CT105 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-monkey IL-2 |
CT112 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-monkey IL-10 |
CT107 |
U-CyTech |
0.5 mg |
EUR 312 |
mAb mouse anti-monkey IL-13 |
CT109 |
U-CyTech |
0.5 mg |
EUR 312 |
Rabbit anti-Mouse IL-12/IL-23 p40 mAb (CAP) |
RM17947 |
Abclonal |
500μg |
Ask for price |
Rabbit anti-Mouse IL-12/IL-23 p40 mAb (DET) |
RM17948 |
Abclonal |
500μg |
Ask for price |
Anti-NF-κB p65 Mouse mAb |
E2206026 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-HIV-1 p24 Mouse mAb |
MBS477409-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-HIV-1 p24 Mouse mAb |
MBS477409-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-HIV-1 p24 Mouse mAb |
MBS477410-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-HIV-1 p24 Mouse mAb |
MBS477410-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
Anti-HIV-1 p24 Mouse mAb |
MBS477411-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Anti-HIV-1 p24 Mouse mAb |
MBS477411-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
mAb mouse anti-human IL-13 FITC-labeled |
CT246 |
U-CyTech |
50 µg |
EUR 312 |
Rabbit anti-Human IL-12/IL-23 p40 mAb (CAP) |
RM17931 |
Abclonal |
500μg |
Ask for price |
Rabbit anti-Human IL-12/IL-23 p40 mAb (DET) |
RM17932 |
Abclonal |
100μg |
Ask for price |
mouse anti-HIV-1 p24 mAb(1M) |
E409C36-mA100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
mouse anti-HIV-1 p24 mAb(2M) |
E409C36-mNbFc100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
Mouse anti-HIV-1 p24 mAb (1M) |
MBS8576858-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-HIV-1 p24 mAb (1M) |
MBS8576858-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (1M) |
MBS8576858-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (1M) |
MBS8576858-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (1M) |
MBS8576858-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (2M) |
MBS8576859-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Mouse anti-HIV-1 p24 mAb (2M) |
MBS8576859-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (2M) |
MBS8576859-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse anti-HIV-1 p24 mAb (2M) |
MBS8576859-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
The Level of Plasma IL-12P40, Plasma IL-12P70, and the IL-12P70 supernatant was significantly higher in patients with no rather than in HCS, while there was no significant difference in the levels of plasma IL-23, or IL-12P40 supernatan. The level of plasma IL-12P70, IL-12P40 supernatant, and the IL-12P70 supernatant is significantly higher in patients with alleles risk than not. CD4 + IFN-γ + cell ratio is significantly higher in patients with risk alleles, while CD4 cells + IL-17A + does not show differences.