Recently there was a paradigm shift in the field of Dendritic immunotherapy (DC) Dendritic, where several clinical studies have confirmed feasibility and excellence using DCS originating from human blood isolated directly above distinguished vitro. There are two main DC sets found in the blood; Plasmacytoid DCS (PDC) and Myeloid DCS (MDCs), and both have been clinically tested. CD1C + MDC is a cell that presents a highly efficient antigen that has the ability to issue IL-12P70, while PDC is the cells that are excluded professionally ifn-α which is proven to induce default immune response in melanoma patients.

Therefore, combining MDC and PDCs poses as an attractive multi-function vaccine approach. However, the type of IFNS has been reported to inhibit the production of IL-12P70 and MDC-induced MDC cell activation. In this study, we investigate the effect of IFN-α in the maturation and MDC function. We show that the two IFN-α PDC is recuminated and activated greatly increases MDC maturation and increases IL-12P70 production. MDC and PDCs that are cultured together also have beneficial effects on NK activation and cells and also increases IFN-γ production with allogeneic t cells. Conversely, the existence of type I IFN reduces proliferative cell response. The presence is only a small part of PDC active enough for this effect and the ratio needed between the set of insecure parts. Taken together, these results support the use of MDC and PDC combined into one immunotherapy vaccine with a broad immunostimulator feature.

The intraperitoneal government of Chimeric Immunogen (ROP) novel raises IFN-γ and <em> il </ em> 12p70 </ em> protective immune response in Balb / C mice against Brucella virulent.

Immunologically active chimeric protein recording consisting of the OMP19 and P39 domains of B. abortion (ROP), purified in conditions of denaturation on expression in E. coli BL21 (DE3) and repair with dynamic forms. Imuno Protective ROP properties are evaluated by challenging balb / c intraperiterally (IP) with infective species Brucella in the absence or presence of adjuvants, such as aluminum hydroxide gel (AL), or complete freund (FCA) / Adjuvant Freund (IFA) , Strangely, after the second decline, mice received ROP per se found immunogenic in terms of IgG response with the dominant expression of IGG2A and IFN-γ which was significant with LFus T cells, indicating that ROP was a strong induction of anti-brucella immunity.

The produced anti-rop antibodies recognize the original OMP19 and P39 among Brucella species and a single band and a single band against Chimera in immunoblot. Enhanced antibody response and proportional to the combination of IgG isotypes that vary in mice are prepared and driven by ROP on adjuvant. However, ROP + FCA / IFA formulation was found most effectively in the lymphocyte test remembering significant induction (P <0.001) the proliferation index (PI) and the increase in cytokines combined (IFN-γ, IL-2 and IL -12P70) of ROP + AL In response to ROP recounts.

Furthermore, in vitro defensive tests revealed that compared to anti-rop antisera, anti-sera polyclonal of ROP + Adjuvants showed an increase in RAW264.7 cells on virulent challenges by B. Melitensis 16M and B. abortion 544. In addition, compared to Sham Group , Enumeration of CFU Brucella after a challenge with the species above shows a significant reduction of bacteria (P <0.01) (CFU log) in the macrophage cell line and vaccinated rat organs. Overall, a relatively higher reduction and was more quickly noticed on vaccinated mice with a similar number of pure antigens in the Freund Adjuvant. The ability to induce immune protection directed by the absence of adjuvant support, crashing ROP as a reasonable participant to develop a chimeric-based subunit vaccine against Brucella.

Brucella abortion strains 19 invades, survive, and activate human dendritic cells, and induce the secretion of <em> il </ em> 12p70 </ em> but not <el> – 23.

Vector bacteria has been proposed as a new vaccine strategy to encourage strong cellular immunity. Entitulated Brucella strains consist of a promising vector candidate because they have the potential to induce the response of immune mediated CD4 (+) and CD8 (+) which are strong with the absence of excessive inflammation such as observed with other gram-negative bacteria. However, some strains of Brucella disturb the maturation of dendritic cells (DCS), which are important for the priming of antigen specific T cells. In this study, we investigated DC interactions which were derived from the human monocyte smoothly weakening B. Abotor strain 19, which had previously been employed successfully to vaccinate livestock.

We first saw the potential of S19 to inhibit the maturation of DC caused by cytokines; However, infected cells are expressed by CD25, CD40, CD80, and CD86 to the extent that are comparable as DC that is not infected and mature. Furthermore, S19 activates DCS in the absence of exogenous stimuli, increases HLA-ABC and HLA-DR expression, and is able to survive intracellularly without causing cytotoxicity. Thus, DCS provides a cellular niche for Brucella which survives in vivo as a permanent source of antigen. S19-infected DCS produces IL-12 / 23P40, IL-12P70, and IL-10, but not IL-23. While hot bacteria also activate DCS, the soluble mediator is not involved in the activation of S19 induced human DC. HEK 293 Transfectants revealed cellular activation by S19 mainly through receptor involvement such as toll (TLR) 2. Thus, as an immunological prerequisite for the efficacy of vaccines, B. S19 abortion has the potential to infect and potentially activate (most likely through TLR2) human DCS to produce cytokines that promote TH1.

Locus new vulnerability in <em> il </ em> Region 12b is associated with the pathophysiology of Takayasu arteritis to <em> il </ em> -12p40 and <em> il </ em> <br70 </ em> production.

A previous study revealed the relationship between the vulnerability to Takayasu arteritis (no) and one nucleotide polymorphism (SNP) RS6871626 located in IL12B, which encodes Interleukin (IL) -12P40, general components of IL-12P70 and IL-23. We investigate this cytokine expression in patients with no, emphasizing them into them with or without risk of alleles at SNP RS6871626.

The Level of Plasma IL-12P40, IL-12P70, and IL-23 were quantified in 44 patients with no and 19 healthy controls (HCS) by testing enzyme immunosorbents. Monocytes are obtained from 20 patients with no and 14 HCS, treated with interferon-γ (IFN-γ) and lipopolysaccharide, and then the cytokine supernatis is quantified. In addition, IFN-γ + or IL-17A + cell ratios to CD4 + cells are measured by the analysis of cytometric flow of peripheral mononuclear blood cells.

Human IL-12p70 ELISPOT kit
CT240-T5	U-CyTech	5-plate	EUR 694.8

pAb rabbit anti-human IL-12p70 Biotin-labeled
CT274	U-CyTech	0.5 mg	EUR 416.4

Human IL-12p70 ELISPOT antibody pair
CT650-10	U-CyTech	10-plate	EUR 633.6

Human IL-12p70 ELISPOT antibody pair
CT650-20	U-CyTech	20-plate	EUR 1107.6

Human IL-12p70 ELISA antibody pair
CT750-10	U-CyTech	10-plate	EUR 656.4

Human IL-12p70 ELISA antibody pair
CT750-20	U-CyTech	20-plate	EUR 1118.4

Rat IL-12P70 ELISA Kit
DEIA1175	Creative Diagnostics	96T	EUR 1132.8
Description: The Rat IL-12P70 ELISA kit is designed to detect and quantify the level of Rat IL-12P70 in cell culture supernatant, serum, plasma and tissue. This kit is for research use only and not intended for diagnostic purposes.

mAb mouse anti-human IL-13
CT227	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-2
CT252	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-4
CT253	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-10
CT254	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-5
CT255	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-10
CT256	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-8
CT264	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-1β
CT269	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-6
CT272	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-23p19
CT284	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-23p19
CT285	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-17A
CT291	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-17A
CT292	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-17F
CT293	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-31
CT686	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-31
CT687	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-33
CT688	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-33
CT689	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-12/23p40
CT257	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-12/23p40
CT275	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse/human IL-5
CT694	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-rat IL-4
CT028	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-rat IL-4
CT029	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-4
CT103	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-6
CT104	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-5
CT105	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-10
CT107	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-13
CT109	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-2
CT112	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-4
CT324	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-10
CT325	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-9
CT326	U-CyTech	0.5 mg	EUR 312

mAb hamster anti-mouse IL-9
CT327	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-2
CT335	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-2
CT336	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-4
CT337	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-2
CT589	U-CyTech	0.5 mg	EUR 312

mAb rat anti-mouse IL-6
CT593	U-CyTech	0.5 mg	EUR 312

mAb rat anti-human IL-5
CT262	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IL-13 FITC-labeled
CT246	U-CyTech	50 µg	EUR 312

mAb mouse anti-human IL-6
CT263	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-monkey IL-13 Cy5-labeled
CT119	U-CyTech	50 µg	EUR 312

mAb mouse anti-monkey IL-13 FITC-labeled
CT120	U-CyTech	50 µg	EUR 312

mAb rat anti-mouse IL-2 Biotin-labeled
CT588	U-CyTech	0.5 mg	EUR 416.4

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 418.8

Mouse Anti-Human CD3 mAb
CM001-100ug	SAB	100ug	EUR 250.8

Mouse Anti-Human CD3 mAb
CM001-25ug	SAB	25ug	EUR 154.8

Mouse Anti-Human CD28 mAb
CM002-100ug	SAB	100ug	EUR 267.6

Mouse Anti-Human CD28 mAb
CM002-25ug	SAB	25ug	EUR 163.2

Mouse Anti-Human CD40 mAb
CM005-100ug	SAB	100ug	EUR 294

Mouse Anti-Human CD40 mAb
CM005-25ug	SAB	25ug	EUR 163.2

Mouse Anti-Human CD80 mAb
CM015-100ug	SAB	100ug	EUR 224.4

Mouse Anti-Human CD80 mAb
CM015-25ug	SAB	25ug	EUR 146.4

Mouse Anti-Human ICOS mAb
CM078-100ug	SAB	100ug	EUR 346.8

Mouse Anti-Human ICOS mAb
CM078-25ug	SAB	25ug	EUR 250.8

mAb mouse anti-human Perforin
CT685	U-CyTech	0.5 mg	EUR 312

Mouse Anti-Human CD133 mAb
CS001-100ug	SAB	100ug	EUR 572.4

Mouse Anti-Human CD133 mAb
CS001-25ug	SAB	25ug	EUR 242.4

Mouse Anti-Human CD3 mAb
P1059-25ug	SAB	25ug	EUR 154.8

Mouse Anti-Human CD8 mAb
P1060-25ug	SAB	25ug	EUR 163.2

Mouse Anti-Human CD68 mAb
P1061-25ug	SAB	25ug	EUR 181.2

Mouse Anti-Human CD47 mAb
P1068-25ug	SAB	25ug	EUR 267.6

Mouse anti-LTA mAb
0270-001	IBT Bioservices	200ug	EUR 272.4
Description: Related to: Staphylococcus Applications: ELISA

Mouse Anti-Human B7-H4 mAb
CM045-100ug	SAB	100ug	EUR 633.6

Mouse Anti-Human B7-H4 mAb
CM045-25ug	SAB	25ug	EUR 294

Mouse Anti-Human B7-H4 mAb
CM046-100ug	SAB	100ug	EUR 633.6

Mouse Anti-Human B7-H4 mAb
CM046-25ug	SAB	25ug	EUR 294

Mouse Anti-Human CD252 (OX40L) mAb
CM050-100ug	SAB	100ug	EUR 267.6

Mouse Anti-Human CD252 (OX40L) mAb
CM050-25ug	SAB	25ug	EUR 138

Mouse Anti-Human CD252 (OX40L) mAb
CM062-100ug	SAB	100ug	EUR 285.6

Mouse Anti-Human CD252 (OX40L) mAb
CM062-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD184 (CXCR4) mAb
CM066-100ug	SAB	100ug	EUR 381.6

Mouse Anti-Human CD184 (CXCR4) mAb
CM066-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD272 (BTLA) mAb
CM070-100ug	SAB	100ug	EUR 546

Mouse Anti-Human CD272 (BTLA) mAb
CM070-25ug	SAB	25ug	EUR 224.4

Mouse Anti-Human CD258 (LIGHT) mAb
CM074-100ug	SAB	100ug	EUR 381.6

Mouse Anti-Human CD258 (LIGHT) mAb
CM074-25ug	SAB	25ug	EUR 267.6

Mouse Anti-Human B7-H5 mAb
CM082-100ug	SAB	100ug	EUR 529.2

Mouse Anti-Human B7-H5 mAb
CM082-25ug	SAB	25ug	EUR 267.6

Mouse Anti-Human B7-H5 mAb
CM083-100ug	SAB	100ug	EUR 729.6

Mouse Anti-Human B7-H5 mAb
CM083-25ug	SAB	25ug	EUR 381.6

mAb mouse anti-human IFN-γ
CT215	U-CyTech	0.5 mg	EUR 334.8

mAb mouse anti-human IFN-γ
CT216	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IFN-α
CT251	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human TNF-α
CT258	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human TNF-α
CT260	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human GM-CSF
CT266	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human Granzyme B
CT268	U-CyTech	0.5 mg	EUR 463.2

mAb mouse anti-human Granzyme B
CT270	U-CyTech	0.5 mg	EUR 463.2

mAb mouse anti-human TNF-α
CT271	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human MCP-1
CT690	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human MCP-1
CT691	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IP-10
CT692	U-CyTech	0.5 mg	EUR 312

mAb mouse anti-human IP-10
CT693	U-CyTech	0.5 mg	EUR 312

Mouse anti-Human CD3, Purified mAb
28003-100ul	SAB	100ul	EUR 302.4

Mouse anti-Human CD4, Purified mAb
28010-100ul	SAB	100ul	EUR 302.4

Mouse anti-Human CD8, Purified mAb
28025-100ul	SAB	100ul	EUR 302.4

Mouse anti-Human CD14, Purified mAb
28050-100ul	SAB	100ul	EUR 302.4

Mouse anti-Human CD19, Purified mAb
28071-100ul	SAB	100ul	EUR 302.4

Mouse anti-Human CD45, Purified mAb
28141-100ul	SAB	100ul	EUR 302.4

Mouse Anti-Human B7-H4 mAb
P1064-25T	SAB	25T	EUR 294

Mouse Anti-Human B7-H5 mAb
P1065-25ug	SAB	25ug	EUR 381.6

Anti-human CD47 mAb
CM096-100ug	SAB	100ug	EUR 416.4

Anti-human CD47 mAb
CM096-25ug	SAB	25ug	EUR 242.4

Anti-human CD45 mAb
CM100-100ug	SAB	100ug	EUR 146.4

Anti-human CD45 mAb
CM100-25ug	SAB	25ug	EUR 103.2

mAb mouse anti-monkey CD3
CT161	U-CyTech	0.5 mg	EUR 457.2

Mouse anti GST-Tag mAb
AE001	Abclonal	50 ul	EUR 234

Mouse anti mCherry-Tag mAb
AE002	Abclonal	50 ul	EUR 267.6

Mouse anti His-Tag mAb
AE003	Abclonal	50 ul	EUR 211.2

Mouse anti DDDDK-Tag mAb
AE005	Abclonal	50 ul	EUR 234

Mouse anti HA-Tag mAb
AE008	Abclonal	50 ul	EUR 211.2

Mouse anti Myc-Tag mAb
AE010	Abclonal	50 ul	EUR 211.2

Mouse anti GFP-Tag mAb
AE012	Abclonal	50 ul	EUR 211.2

Mouse anti MBP-Tag mAb
AE016	Abclonal	50 ul	EUR 234

Mouse anti V5-Tag mAb
AE017	Abclonal	100 ul	EUR 273.6

Mouse anti T7-Tag mAb
AE018	Abclonal	100 ul	EUR 307.2

Mouse anti RFP-Tag mAb
AE020	Abclonal	100 ul	EUR 273.6

Mouse anti TAP-Tag mAb
AE021	Abclonal	100 ul	EUR 307.2

Mouse anti Trx-Tag mAb
AE023	Abclonal	100 ul	EUR 307.2

Mouse anti HA-Tag mAb
AE065	Abclonal	50 ul	EUR 211.2

Mouse anti-Hla mAb (8B7)
0210-001	IBT Bioservices	100ug	EUR 540
Description: Related to: Staphylococcus Applications: ELISA, WB

Mouse anti-Hla mAb (6C12)
0210-005	IBT Bioservices	100ug	EUR 540
Description: Related to: Staphylococcus Applications: ELISA, WB

Mouse anti-SEB mAb (3D10)
0220-009	IBT Bioservices	100ug	EUR 486
Description: Related to: Staphylococcus Applications: ELISA, WB

Mouse anti-SEB mAb (2C1)
0220-013	IBT Bioservices	100ug	EUR 394.8
Description: Related to: Staphylococcus Applications: ELISA, WB

anti-mouse IgG mAb, AP
E409B09-AP100	EnoGene	100μL	EUR 294

anti-mouse IgG mAb, HRP
E409B09-HRP100	EnoGene	100μL	EUR 294

anti-mouse IgG1 mAb, AP
E409B11-AP100	EnoGene	100μL	EUR 294

anti-mouse IgG1 mAb, HRP
E409B11-HRP100	EnoGene	100μL	EUR 294

anti-mouse IgG2a mAb, AP
E409B13-AP100	EnoGene	100μL	EUR 294

anti-mouse IgG2a mAb, HRP
E409B13-HRP100	EnoGene	100μL	EUR 294

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

Mouse Anti-Human CD28, FITC Conjugated mAb
CM003-100T	SAB	100T	EUR 372

Mouse Anti-Human CD28, FITC Conjugated mAb
CM003-25T	SAB	25T	EUR 198

Mouse Anti-Human CD28, PE Conjugated mAb
CM004-100T	SAB	100T	EUR 441.6

Mouse Anti-Human CD28, PE Conjugated mAb
CM004-25T	SAB	25T	EUR 242.4

Mouse Anti-Human CD40, FITC Conjugated mAb
CM006-100T	SAB	100T	EUR 363.6

Mouse Anti-Human CD40, FITC Conjugated mAb
CM006-25T	SAB	25T	EUR 198

Mouse Anti-Human CD40, PE Conjugated mAb
CM007-100T	SAB	100T	EUR 433.2

Mouse Anti-Human CD40, PE Conjugated mAb
CM007-25T	SAB	25T	EUR 232.8

Mouse Anti-Human CD40, Biotin Conjugated mAb
CM008-100ug	SAB	100ug	EUR 277.2

Mouse Anti-Human CD40, Biotin Conjugated mAb
CM008-25ug	SAB	25ug	EUR 163.2

Mouse Anti-Human CD80, FITC Conjugated mAb
CM016-100T	SAB	100T	EUR 372

Mouse Anti-Human CD80, FITC Conjugated mAb
CM016-25T	SAB	25T	EUR 207.6

Mouse Anti-Human CD80, PE Conjugated mAb
CM017-100T	SAB	100T	EUR 441.6

Mouse Anti-Human CD80, PE Conjugated mAb
CM017-25T	SAB	25T	EUR 224.4

Mouse Anti-Human CD80, Biotin Conjugated mAb
CM018-100ug	SAB	100ug	EUR 328.8

Mouse Anti-Human CD80, Biotin Conjugated mAb
CM018-25ug	SAB	25ug	EUR 181.2

Mouse Anti-Human CD279 (PD-1) mAb
CM019-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human CD279 (PD-1) mAb
CM019-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD279 (PD-1) mAb
CM020-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human CD279 (PD-1) mAb
CM020-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD279 (PD-1) mAb
CM021-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human CD279 (PD-1) mAb
CM021-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD274 (PD-L1) mAb
CM025-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human CD274 (PD-L1) mAb
CM025-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD274 (PD-L1) mAb
CM026-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human CD274 (PD-L1) mAb
CM026-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD274 (PD-L1) mAb
CM027-100ug	SAB	100ug	EUR 267.6

Mouse Anti-Human CD274 (PD-L1) mAb
CM027-25ug	SAB	25ug	EUR 181.2

Mouse Anti-Human CD273 (PD-L2) mAb
CM031-100ug	SAB	100ug	EUR 250.8

Mouse Anti-Human CD273 (PD-L2) mAb
CM031-25ug	SAB	25ug	EUR 154.8

Mouse Anti-Human GL50 (B7-H2) mAb
CM035-100ug	SAB	100ug	EUR 337.2

Mouse Anti-Human GL50 (B7-H2) mAb
CM035-25ug	SAB	25ug	EUR 198

Mouse Anti-Human GL50 (B7-H2) mAb
CM036-100ug	SAB	100ug	EUR 416.4

Mouse Anti-Human GL50 (B7-H2) mAb
CM036-25ug	SAB	25ug	EUR 242.4

Mouse Anti-Human CD276 (B7-H3) mAb
CM040-100ug	SAB	100ug	EUR 676.8

Mouse Anti-Human CD276 (B7-H3) mAb
CM040-25ug	SAB	25ug	EUR 363.6

Mouse Anti-Human CD276 (B7-H3) mAb
CM041-100ug	SAB	100ug	EUR 363.6

Mouse Anti-Human CD276 (B7-H3) mAb
CM041-25ug	SAB	25ug	EUR 198

Mouse Anti-Human CD137 (4-1BB) mAb
CM054-100ug	SAB	100ug	EUR 285.6

Mouse Anti-Human CD137 (4-1BB) mAb
CM054-25ug	SAB	25ug	EUR 198

Mouse Anti-Human ICOS, FITC Conjugated mAb
CM079-100T	SAB	100T	EUR 511.2

Mouse Anti-Human ICOS, FITC Conjugated mAb
CM079-25T	SAB	25T	EUR 294

Mouse Anti-Human ICOS, PE Conjugated mAb
CM080-100T	SAB	100T	EUR 555.6

Mouse Anti-Human ICOS, PE Conjugated mAb
CM080-25T	SAB	25T	EUR 312

Mouse Anti-Human ICOS, Biotin Conjugated mAb
CM081-100ug	SAB	100ug	EUR 572.4

Mouse Anti-Human ICOS, Biotin Conjugated mAb
CM081-25ug	SAB	25ug	EUR 224.4

Mouse Anti-Human CD233 (LAG-3) mAb
CM087-100ug	SAB	100ug	EUR 555.6

Mouse Anti-Human CD233 (LAG-3) mAb
CM087-25ug	SAB	25ug	EUR 285.6

Mouse Anti-Human CD233 (LAG-3) mAb
CM088-100ug	SAB	100ug	EUR 555.6

Mouse Anti-Human CD233 (LAG-3) mAb
CM088-25ug	SAB	25ug	EUR 285.6

Mouse Anti-Human CD47, FITC Conjugated mAb
CM097-100T	SAB	100T	EUR 441.6

Mouse Anti-Human CD47, FITC Conjugated mAb
CM097-25T	SAB	25T	EUR 242.4

Mouse Anti-Human CD47, PE Conjugated mAb
CM098-100T	SAB	100T	EUR 486

Mouse Anti-Human CD47, PE Conjugated mAb
CM098-25T	SAB	25T	EUR 250.8

Mouse Anti-Human CD47, Biotin Conjugated mAb
CM099-100ug	SAB	100ug	EUR 424.8

Mouse Anti-Human CD47, Biotin Conjugated mAb
CM099-25ug	SAB	25ug	EUR 259.2

Mouse Anti-Human CD133, FITC Conjugated mAb
CS002-100T	SAB	100T	EUR 572.4

Mouse Anti-Human CD133, FITC Conjugated mAb
CS002-25T	SAB	25T	EUR 267.6

The Level of Plasma IL-12P40, Plasma IL-12P70, and the IL-12P70 supernatant was significantly higher in patients with no rather than in HCS, while there was no significant difference in the levels of plasma IL-23, or IL-12P40 supernatan. The level of plasma IL-12P70, IL-12P40 supernatant, and the IL-12P70 supernatant is significantly higher in patients with alleles risk than not. CD4 + IFN-γ + cell ratio is significantly higher in patients with risk alleles, while CD4 cells + IL-17A + does not show differences.