dendritic cell (DC) based vaccine is a promising strategy for cancer immunotherapy. However, clinical trials have shown only limited efficacy, demonstrates the need to optimize protocols for Human DC vaccine preparation. In this study, we systematically compared five different Human vaccines DC maturation protocols used in clinical trials: (1) four-cytokine cocktail (TNF-α, IL -6, IL -1β, and PGE2); (2) cocktails α-DC-cytokine (TNF-α, IL -1β, IFN-α, IFN-γ, and poly I: C); (3) lipopolysaccharide (LPS) / IFN-γ; (4) TNF-α and PGE2; and (5) Trimix (mRNA encoding CD40L, CD70, and constitutively activated Toll-like receptor 4 electroporated into immature DC).
We found that four cytokine cocktail induced high levels of costimulatory and HLA molecules, and CCR7, in DC. Mature DC (MDCs) matured with a cocktail of four cytokines have higher viability than those obtained with other protocols. Based on these features, we chose four cytokine cocktail protocols to further enhance the ability of immunization of DC by introducing exogenous genes. We show that the introduction of exogenous Bcl-2 increased DC survival. Furthermore, introducing the IL – 12p70 rescued inhibition of IL -12 secretion by PGE2 without damaging the DC phenotype.
Introducing both Bcl-2 and IL – 12p70 mRNA into DC induced enhanced cytomegalovirus pp65-specific CD8 + T cells secreting IFN-γ and TNF-α , Taken together, our data demonstrate that DCs matured by a cocktail of four cytokines combined with exogenous Bcl-2 and IL – 12p70 gene expression is a promising approach for clinical applications in cancer immunotherapy.
Enhanced Human T Lymphocyte Antigen Priming by Cytokine-Matured Dendritic Cells Overexpressing Bcl-2 and IL-12. Mycobacterium avium subsp. paratuberculosis MAP1889c Protein Induces Maturation of Dendritic cells and Th2-biased Drives Immune Responses.
Mycobacterium avium subsp . paratuberculosis (MAP) is the causative agent of chronic granulomatous bowel disease in animals and is associated with various autoimmune diseases in Human including Crohn’s disease. A good understanding of host-protective immune response and antibacterial immunity is controlled by MAP and its components may contribute to the development of effective control strategies.
MAP1889c seroreactive identified as an antigen in patients with Crohn’s disease. In this study, we investigated the immunological function of MAP1889c in dendritic cells (DC). MAP1889c stimulated DC to increase the expression of molecular co-stimulatory (CD80 and CD86) and molecular complex class major histocompatibility (MHC) and the secret interleukin higher ( IL ) – 10 and moderate IL -6, tumor necrosis factor (TNF) -α, and IL – 12p70 level through Toll-like receptor (TLR) 4 lanes.
MAP1889c-induced DC activation mediated by mitogen-activated protein kinases (MAPKs), cAMPp-response element binding protein (CREB), and nuclear factor kappa B (NF-kB). In particular, the signal is essential for MAP1889c CREB-mediated IL -10 production but not TNF-α and IL – 12p70 . In addition, DC-mature MAP1889c induced T cell proliferation and drove Th2 response.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog)
4-PAA071Ca01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog)
4-PAA071Ca02
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Pig)
4-PAA071Po01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Pig Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rat)
4-PAA071Ra01
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Description: A Rabbit polyclonal antibody against Rat Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Goat)
4-PAA071Cp01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Goat Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Horse)
4-PAA071Eq01
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Description: A Rabbit polyclonal antibody against Horse Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Human)
4-PAA071Hu01
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Description: A Rabbit polyclonal antibody against Human Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Human)
4-PAA071Hu02
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Description: A Rabbit polyclonal antibody against Human Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Mouse)
4-PAA071Mu01
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Description: A Rabbit polyclonal antibody against Mouse Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Mouse)
4-PAA071Mu02
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Description: A Rabbit polyclonal antibody against Mouse Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Bovine)
4-PAA071Bo01
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Description: A Rabbit polyclonal antibody against Bovine Interleukin 1 Alpha (IL1a)
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rabbit)
4-PAA071Rb51
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Description: A Guinea polyclonal antibody against Rabbit Interleukin 1 Alpha (IL1a)
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2139433-01mL
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0.1mL
EUR 190
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2139433-02mL
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0.2mL
EUR 235
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2139433-05mL
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0.5mL
EUR 400
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2139433-1mL
MyBiosource
1mL
EUR 485
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2139433-5mL
MyBiosource
5mL
EUR 1355
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028534-01mL
MyBiosource
0.1mL
EUR 170
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028534-02mL
MyBiosource
0.2mL
EUR 205
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028534-05mL
MyBiosource
0.5mL
EUR 330
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028534-1mL
MyBiosource
1mL
EUR 405
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MBS2028534-5mL
MyBiosource
5mL
EUR 1100
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2002449-01mL
MyBiosource
0.1mL
EUR 165
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2002449-02mL
MyBiosource
0.2mL
EUR 200
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MBS2002449-05mL
MyBiosource
0.5mL
EUR 325
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2002449-1mL
MyBiosource
1mL
EUR 395
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MBS2002449-5mL
MyBiosource
5mL
EUR 1075
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2111340-01mL
MyBiosource
0.1mL
EUR 180
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2111340-02mL
MyBiosource
0.2mL
EUR 225
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MBS2111340-05mL
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0.5mL
EUR 380
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MBS2111340-1mL
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1mL
EUR 465
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MBS2111340-5mL
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5mL
EUR 1280
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2007346-01mL
MyBiosource
0.1mL
EUR 175
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MBS2007346-02mL
MyBiosource
0.2mL
EUR 220
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MBS2007346-05mL
MyBiosource
0.5mL
EUR 365
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MBS2007346-1mL
MyBiosource
1mL
EUR 445
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MBS2007346-5mL
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5mL
EUR 1220
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2002095-01mL
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0.1mL
EUR 190
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MBS2002095-02mL
MyBiosource
0.2mL
EUR 230
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MBS2002095-05mL
MyBiosource
0.5mL
EUR 390
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MBS2002095-1mL
MyBiosource
1mL
EUR 475
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MBS2002095-5mL
MyBiosource
5mL
EUR 1310
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2002184-01mL
MyBiosource
0.1mL
EUR 180
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MBS2002184-02mL
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0.2mL
EUR 225
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MBS2002184-05mL
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0.5mL
EUR 380
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MBS2002184-1mL
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1mL
EUR 465
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MBS2002184-5mL
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5mL
EUR 1280
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MBS2003462-01mL
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EUR 190
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MBS2003462-02mL
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0.2mL
EUR 230
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MBS2003462-05mL
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EUR 390
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MBS2003462-1mL
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1mL
EUR 475
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MBS2003462-5mL
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5mL
EUR 1310
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MBS2004781-01mL
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EUR 175
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MBS2004781-02mL
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EUR 220
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MBS2004781-05mL
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EUR 365
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MBS2004781-1mL
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1mL
EUR 445
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MBS2004781-5mL
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5mL
EUR 1220
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MBS2004825-01mL
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0.1mL
EUR 140
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MBS2004825-02mL
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0.2mL
EUR 165
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MBS2004825-05mL
MyBiosource
0.5mL
EUR 250
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MBS2004825-1mL
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1mL
EUR 290
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MBS2004825-5mL
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5mL
EUR 765
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2005187-01mL
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0.1mL
EUR 170
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MBS2005187-02mL
MyBiosource
0.2mL
EUR 215
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MBS2005187-05mL
MyBiosource
0.5mL
EUR 350
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MBS2005187-1mL
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1mL
EUR 425
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MBS2005187-5mL
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5mL
EUR 1160
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MBS2026045-01mL
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0.1mL
EUR 175
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MBS2026045-02mL
MyBiosource
0.2mL
EUR 220
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MBS2026045-05mL
MyBiosource
0.5mL
EUR 365
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MBS2026045-1mL
MyBiosource
1mL
EUR 445
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MBS2026045-5mL
MyBiosource
5mL
EUR 1220
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MBS2026480-01mL
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0.1mL
EUR 165
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MBS2026480-02mL
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0.2mL
EUR 200
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MBS2026480-05mL
MyBiosource
0.5mL
EUR 320
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MBS2026480-1mL
MyBiosource
1mL
EUR 395
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2026480-5mL
MyBiosource
5mL
EUR 1070
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028141-01mL
MyBiosource
0.1mL
EUR 170
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028141-02mL
MyBiosource
0.2mL
EUR 205
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028141-05mL
MyBiosource
0.5mL
EUR 330
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028141-1mL
MyBiosource
1mL
EUR 405
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
MBS2028141-5mL
MyBiosource
5mL
EUR 1100
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Bo01
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100ul
EUR 265
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Ca01
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100ul
EUR 252
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Ca02
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100ul
EUR 252
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Cp01
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100ul
EUR 272
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Cp02
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100ul
EUR 281
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Eq01
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100ul
EUR 272
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Gu01
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100ul
EUR 252
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Hu01
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100ul
EUR 221
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Hu02
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100ul
EUR 220
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Mu01
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100ul
EUR 227
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Mu02
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100ul
EUR 227
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Ra01
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100ul
EUR 154
Polyclonal Antibody to Interleukin 1 Alpha (IL1a)
PAA071Rb51
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100ul
EUR 239
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), PE
4-PAA071Ca01-PE
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with PE.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), PE
4-PAA071Ca02-PE
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with PE.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Pig), PE
4-PAA071Po01-PE
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Description: A Rabbit polyclonal antibody against Pig Interleukin 1 Alpha (IL1a). This antibody is labeled with PE.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rat), PE
4-PAA071Ra01-PE
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Description: A Rabbit polyclonal antibody against Rat Interleukin 1 Alpha (IL1a). This antibody is labeled with PE.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), APC
4-PAA071Ca01-APC
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with APC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), Cy3
4-PAA071Ca01-Cy3
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with Cy3.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), HRP
4-PAA071Ca01-HRP
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with HRP.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), APC
4-PAA071Ca02-APC
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with APC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), Cy3
4-PAA071Ca02-Cy3
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with Cy3.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), HRP
4-PAA071Ca02-HRP
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Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with HRP.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Goat), PE
4-PAA071Cp01-PE
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Description: A Rabbit polyclonal antibody against Goat Interleukin 1 Alpha (IL1a). This antibody is labeled with PE.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Pig), APC
4-PAA071Po01-APC
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Description: A Rabbit polyclonal antibody against Pig Interleukin 1 Alpha (IL1a). This antibody is labeled with APC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Pig), Cy3
4-PAA071Po01-Cy3
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Description: A Rabbit polyclonal antibody against Pig Interleukin 1 Alpha (IL1a). This antibody is labeled with Cy3.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Pig), HRP
4-PAA071Po01-HRP
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Description: A Rabbit polyclonal antibody against Pig Interleukin 1 Alpha (IL1a). This antibody is labeled with HRP.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rat), APC
4-PAA071Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Interleukin 1 Alpha (IL1a). This antibody is labeled with APC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rat), Cy3
4-PAA071Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Interleukin 1 Alpha (IL1a). This antibody is labeled with Cy3.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Rat), HRP
4-PAA071Ra01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 1 Alpha (IL1a). This antibody is labeled with HRP.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), FITC
4-PAA071Ca01-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with FITC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Dog), FITC
4-PAA071Ca02-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 1 Alpha (IL1a). This antibody is labeled with FITC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Goat), APC
4-PAA071Cp01-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Goat Interleukin 1 Alpha (IL1a). This antibody is labeled with APC.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Goat), Cy3
4-PAA071Cp01-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Goat Interleukin 1 Alpha (IL1a). This antibody is labeled with Cy3.
Interleukin 1 Alpha (IL1a) Polyclonal Antibody (Goat), HRP
4-PAA071Cp01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Goat Interleukin 1 Alpha (IL1a). This antibody is labeled with HRP.
Production of lipopolysaccharide (LPS) -mediated pro-inflammatory cytokines and anti-inflammatory cytokine is suppressed and increased respectively by MAP1889c pretreatment in DC and T cells addition, treatment MAP1889c in M. avium -infected macrophages promoted the growth of intracellular bacteria and IL -10 production. These findings indicate that MAP1889c antimycobacterial modulate the host response and can be a potential virulence factor for MAP infection.
