22Q11.2 Removal of Syndrome (22Q11DS) is a genetic disorder that conveys significant risks for the development of social behavior disorders, including autism and schizophrenia. Also known as Digeorge Syndrome, 22Q11DS is the second most common genetic disorder and is characterized by high risk for immune dysfunction, up to 77% of individuals have immune deficiencies that can be identified. We hypothesize that this immune dysfunction can contribute to an increased risk of social behavior disorders seen in 22Q11DS. The current study began explaining this immune deficit and linked it to changes in behavior associated with the disorder.

The serum concentration of a series of cytokines was examined, using immunoassay multiplexay, in sixteen individuals with 22Q11DS and filtered for autism-related behavior using autism diagnostic interviews (ADI-R). This preliminary study examined the correlation between specific immune proteins and each ADI-R algorithm score (social, communication and recurring behavior). IL-1β inflammatory cytokines, as well as the ratio between IL-6 inflammatory cytokines and IL-10 anti-inflammatory cytokines, correlated with social scores (R = 0.851, p = 0.004; r = 0.580, p = 0.018).

In addition, the Inflammatory Cytokin Interferon Gamma and IL-12P70 correlated with recurring behavior (R = 0.795, p = 0.033; R = 0.774, p = 0.002). Interestingly, IL-12 has been reported to increase in autistic children. These data show a positive relationship between the severity of the behavior related to autism and the level of serum concentration of inflammatory cytokines in individuals with 22Q11DS, providing a basis for further investigation.

Transformation Macrofage M2 to M2 induced lipopolysaccharide for <em> il </ em> – <amp> 12p70 </ em> Production blocked by Candida albicans mediated the advantages of EBI3 expression.

Macrophages are heterogeneous cell populations present in all networks. Macrophages can be divided into inflammatory macrophages that are classically activated (M1) and anti-inflammatory macrophages that are activated alternatively (M2). In general it has been accepted that M1 macrophages are polarized in the inflammatory environment to produce pro-inflammatory cytokines, while M2 macrophages are involved in repairing anti-inflammation and assistance networks in wound healing. Endotoxin bacteria (lpopolysaccharide; LPS) are a strong factor in infection, which induces m1 macrophages producing the higher levels of INOS, TNFα and IL-12P70 which determines inflammatory cell responses.

M2 Macrophages can be converted into M1 macrophages after LPS stimulation to promote inflammation. Candida albicans is a commensal mushroom microorganism, which has been advised to encourage immune tolerance; However, the immune tolerance mechanism induced by albicans has not been investigated in detail. IL-35 is an anti-inflammatory cytokine that was recently identified which is a heterodimer protein consisting of genes induced by the Epstein-Barr (EBI3) and IL-12P35 virus. IL-35 shares subunit protein P35, with IL-12P70. IL-12P70 is the most effective cytokine to induce Th1 responses during inflammation. In this study, we showed that C. Albicans who was killed hot (HKC) greatly suppressed the production of IL-12P70 which was induced by LPS in M2 Macrophag.

Candida Albicans induces high level EBI3 expression in M2 Macrophage, which functions as a mechanism for the emphasis of IL-12P70 with competitive binding of general protein subunits (P35) of IL-35 and IL-12P70. To indicate that EBI3 expression has the ability to block the production of IL-12P70 intracellular, Chinese ovarian ovary cell lines (WO) with the expression of Biskutronic IL-12P40 and P35 built, followed by EBI3 ectopic expressions. Over-expression of EBI3 in the cell path that produces IL-12P70 effectively suppresses IL-12P70 production. The secretion of IL-35 was also detected in cell lines, with IL-12P70 production pressed by the deposition of rainfall. However, this secretion was not proven in M2 macrophag following stimulation by HKC.

This can be explained by the Constitutive Expression of the IL-35 receptor (GP130 and IL-12Rβ2) in M2 macrophages for cytokine consumption. The results we have indicated that C. albicans can suppress the response of the inflammatory host in the skin of the mucosa by suppressing the production of IL-12P70 which is induced by LPS. Lower IL-12P70 production can avoid unnecessary Th1 responsibilities to maintain immune tolerance, which may be one mechanism with C. albicans achieve a successful commensal lifestyle without having a detrimental effect on the host’s health.

Nocardia Farcinica activates human dendritic cells and induces interleukin-23 secretion (<em> il </ em> -23) than <em> il </ em> – <em> 12p70 </ em>.

Studying dendritic cell interactions (DCS) with bacteria controlled by immune response mediated by cells can reveal new adjuvants for cellular immunity induction. Murine studies and observations that infect Nocardias are dominantly immunosuppression patients have suggested that these bacteria might have an adjuvant potential.

Human IL-4 ELISA antibody pair
CT742-10	U-CyTech	10-plate	EUR 656.4

Human IL-4 ELISA antibody pair
CT742-20	U-CyTech	20-plate	EUR 1118.4

Human IL-5 ELISA antibody pair
CT743-10	U-CyTech	10-plate	EUR 656.4

Human IL-5 ELISA antibody pair
CT743-20	U-CyTech	20-plate	EUR 1118.4

Human IL-6 ELISA antibody pair
CT744-10	U-CyTech	10-plate	EUR 656.4

Human IL-6 ELISA antibody pair
CT744-20	U-CyTech	20-plate	EUR 1118.4

Human IL-8 ELISA antibody pair
CT748-10	U-CyTech	10-plate	EUR 656.4

Human IL-8 ELISA antibody pair
CT748-20	U-CyTech	20-plate	EUR 1118.4

Human IL-23 ELISA antibody pair
CT567-10	U-CyTech	10-plate	EUR 656.4

Human IL-23 ELISA antibody pair
CT567-20	U-CyTech	20-plate	EUR 1118.4

Human IL-33 ELISA antibody pair
CT569-10	U-CyTech	10-plate	EUR 656.4

Human IL-33 ELISA antibody pair
CT569-20	U-CyTech	20-plate	EUR 1118.4

Human IL-31 ELISA antibody pair
CT570-10	U-CyTech	10-plate	EUR 656.4

Human IL-31 ELISA antibody pair
CT570-20	U-CyTech	20-plate	EUR 1118.4

Human IL-27 ELISA antibody pair
CT574-10	U-CyTech	10-plate	EUR 656.4

Human IL-27 ELISA antibody pair
CT574-20	U-CyTech	20-plate	EUR 1118.4

Human IL-29 ELISA antibody pair
CT575-10	U-CyTech	10-plate	EUR 656.4

Human IL-29 ELISA antibody pair
CT575-20	U-CyTech	20-plate	EUR 1118.4

Human IL-1β ELISA antibody pair
CT576-10	U-CyTech	10-plate	EUR 656.4

Human IL-1β ELISA antibody pair
CT576-20	U-CyTech	20-plate	EUR 1118.4

Human IL-21 ELISA antibody pair
CT580-10	U-CyTech	10-plate	EUR 656.4

Human IL-21 ELISA antibody pair
CT580-20	U-CyTech	20-plate	EUR 1118.4

Human IL-10 ELISA antibody pair
CT745-10	U-CyTech	10-plate	EUR 656.4

Human IL-10 ELISA antibody pair
CT745-20	U-CyTech	20-plate	EUR 1118.4

Human IL-13 ELISA antibody pair
CT746-10	U-CyTech	10-plate	EUR 656.4

Human IL-13 ELISA antibody pair
CT746-20	U-CyTech	20-plate	EUR 1118.4

Human IL-17A ELISA antibody pair
CT566-10	U-CyTech	10-plate	EUR 656.4

Human IL-17A ELISA antibody pair
CT566-20	U-CyTech	20-plate	EUR 1118.4

Human IL-17F ELISA antibody pair
CT568-10	U-CyTech	10-plate	EUR 656.4

Human IL-17F ELISA antibody pair
CT568-20	U-CyTech	20-plate	EUR 1118.4

Human IL-17AF ELISA antibody pair
CT565-10	U-CyTech	10-plate	EUR 656.4

Human IL-17AF ELISA antibody pair
CT565-20	U-CyTech	20-plate	EUR 1118.4

Monkey IL-12/23p40 ELISA antibody pair (detects p40 subunit)
CT719-10	U-CyTech	10-plate	EUR 656.4

Monkey IL-12/23p40 ELISA antibody pair (detects p40 subunit)
CT719-20	U-CyTech	20-plate	EUR 1118.4

Marmoset IL-12/23p40 ELISA antibody pair (detects p40 subunit)
CT775-10	U-CyTech	10-plate	EUR 656.4

Marmoset IL-12/23p40 ELISA antibody pair (detects p40 subunit)
CT775-20	U-CyTech	20-plate	EUR 1118.4

p53R2 Matched ELISA Antibody Pair Set, Human
MBS8118445-15Plates	MyBiosource	15Plates	EUR 800

p53R2 Matched ELISA Antibody Pair Set, Human
MBS8118445-5Plates	MyBiosource	5Plates	EUR 450

p53R2 Matched ELISA Antibody Pair Set, Human
MBS8118445-5x15Plates	MyBiosource	5x15Plates	EUR 3695

15-PGDH Matched ELISA Antibody Pair Set, Human
MBS8118359-15Plates	MyBiosource	15Plates	EUR 800

15-PGDH Matched ELISA Antibody Pair Set, Human
MBS8118359-5Plates	MyBiosource	5Plates	EUR 450

15-PGDH Matched ELISA Antibody Pair Set, Human
MBS8118359-5x15Plates	MyBiosource	5x15Plates	EUR 3695

IL-7 Matched ELISA Antibody Pair Set, Human
MBS8118406-15Plates	MyBiosource	15Plates	EUR 600

IL-7 Matched ELISA Antibody Pair Set, Human
MBS8118406-5Plates	MyBiosource	5Plates	EUR 345

IL-7 Matched ELISA Antibody Pair Set, Human
MBS8118406-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-5 Matched ELISA Antibody Pair Set, Human
MBS8118574-15Plates	MyBiosource	15Plates	EUR 600

IL-5 Matched ELISA Antibody Pair Set, Human
MBS8118574-5Plates	MyBiosource	5Plates	EUR 345

IL-5 Matched ELISA Antibody Pair Set, Human
MBS8118574-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-6 Matched ELISA Antibody Pair Set, Human
MBS8118577-15Plates	MyBiosource	15Plates	EUR 600

IL-6 Matched ELISA Antibody Pair Set, Human
MBS8118577-5Plates	MyBiosource	5Plates	EUR 345

IL-6 Matched ELISA Antibody Pair Set, Human
MBS8118577-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-18 Matched ELISA Antibody Pair Set, Human
MBS8118189-15Plates	MyBiosource	15Plates	EUR 600

IL-18 Matched ELISA Antibody Pair Set, Human
MBS8118189-5Plates	MyBiosource	5Plates	EUR 345

IL-18 Matched ELISA Antibody Pair Set, Human
MBS8118189-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-37 Matched ELISA Antibody Pair Set, Human
MBS8118199-15Plates	MyBiosource	15Plates	EUR 600

IL-37 Matched ELISA Antibody Pair Set, Human
MBS8118199-5Plates	MyBiosource	5Plates	EUR 345

IL-37 Matched ELISA Antibody Pair Set, Human
MBS8118199-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-15 Matched ELISA Antibody Pair Set, Human
MBS8118238-15Plates	MyBiosource	15Plates	EUR 600

IL-15 Matched ELISA Antibody Pair Set, Human
MBS8118238-5Plates	MyBiosource	5Plates	EUR 345

IL-15 Matched ELISA Antibody Pair Set, Human
MBS8118238-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-33 Matched ELISA Antibody Pair Set, Human
MBS8118240-15Plates	MyBiosource	15Plates	EUR 600

IL-33 Matched ELISA Antibody Pair Set, Human
MBS8118240-5Plates	MyBiosource	5Plates	EUR 345

IL-33 Matched ELISA Antibody Pair Set, Human
MBS8118240-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-13 Matched ELISA Antibody Pair Set, Human
MBS8118241-15Plates	MyBiosource	15Plates	EUR 600

IL-13 Matched ELISA Antibody Pair Set, Human
MBS8118241-5Plates	MyBiosource	5Plates	EUR 345

IL-13 Matched ELISA Antibody Pair Set, Human
MBS8118241-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-16 Matched ELISA Antibody Pair Set, Human
MBS8118330-15Plates	MyBiosource	15Plates	EUR 600

IL-16 Matched ELISA Antibody Pair Set, Human
MBS8118330-5Plates	MyBiosource	5Plates	EUR 345

IL-16 Matched ELISA Antibody Pair Set, Human
MBS8118330-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-32 Matched ELISA Antibody Pair Set, Human
MBS8118344-15Plates	MyBiosource	15Plates	EUR 600

IL-32 Matched ELISA Antibody Pair Set, Human
MBS8118344-5Plates	MyBiosource	5Plates	EUR 345

IL-32 Matched ELISA Antibody Pair Set, Human
MBS8118344-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-29 Matched ELISA Antibody Pair Set, Human
MBS8118429-15Plates	MyBiosource	15Plates	EUR 600

IL-29 Matched ELISA Antibody Pair Set, Human
MBS8118429-5Plates	MyBiosource	5Plates	EUR 345

IL-29 Matched ELISA Antibody Pair Set, Human
MBS8118429-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-20 Matched ELISA Antibody Pair Set, Human
MBS8118441-15Plates	MyBiosource	15Plates	EUR 600

IL-20 Matched ELISA Antibody Pair Set, Human
MBS8118441-5Plates	MyBiosource	5Plates	EUR 345

IL-20 Matched ELISA Antibody Pair Set, Human
MBS8118441-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-19 Matched ELISA Antibody Pair Set, Human
MBS8118442-15Plates	MyBiosource	15Plates	EUR 600

IL-19 Matched ELISA Antibody Pair Set, Human
MBS8118442-5Plates	MyBiosource	5Plates	EUR 345

IL-19 Matched ELISA Antibody Pair Set, Human
MBS8118442-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-6R Matched ELISA Antibody Pair Set, Human
MBS8118559-15Plates	MyBiosource	15Plates	EUR 600

IL-6R Matched ELISA Antibody Pair Set, Human
MBS8118559-5Plates	MyBiosource	5Plates	EUR 345

IL-6R Matched ELISA Antibody Pair Set, Human
MBS8118559-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-10 Matched ELISA Antibody Pair Set, Human
MBS8118569-15Plates	MyBiosource	15Plates	EUR 600

IL-10 Matched ELISA Antibody Pair Set, Human
MBS8118569-5Plates	MyBiosource	5Plates	EUR 345

IL-10 Matched ELISA Antibody Pair Set, Human
MBS8118569-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-12 Matched ELISA Antibody Pair Set, Human
MBS8118578-15Plates	MyBiosource	15Plates	EUR 600

IL-12 Matched ELISA Antibody Pair Set, Human
MBS8118578-5Plates	MyBiosource	5Plates	EUR 345

IL-12 Matched ELISA Antibody Pair Set, Human
MBS8118578-5x15Plates	MyBiosource	5x15Plates	EUR 2755

IL-22BP Matched ELISA Antibody Pair Set, Human
MBS8118337-15Plates	MyBiosource	15Plates	EUR 600

IL-22BP Matched ELISA Antibody Pair Set, Human
MBS8118337-5Plates	MyBiosource	5Plates	EUR 345

IL-22BP Matched ELISA Antibody Pair Set, Human
MBS8118337-5x15Plates	MyBiosource	5x15Plates	EUR 2755

Monkey IL-12/23p40 ELISPOT antibody pair (detects p40 subunit)
CT619-10	U-CyTech	10-plate	EUR 633.6

Monkey IL-12/23p40 ELISPOT antibody pair (detects p40 subunit)
CT619-20	U-CyTech	20-plate	EUR 1107.6

Human IL-2 ELISPOT antibody pair
CT641-10	U-CyTech	10-plate	EUR 633.6

Human IL-2 ELISPOT antibody pair
CT641-20	U-CyTech	20-plate	EUR 1107.6

Human IL-4 ELISPOT antibody pair
CT642-10	U-CyTech	10-plate	EUR 633.6

Human IL-4 ELISPOT antibody pair
CT642-20	U-CyTech	20-plate	EUR 1107.6

Human IL-5 ELISPOT antibody pair
CT643-10	U-CyTech	10-plate	EUR 633.6

Human IL-5 ELISPOT antibody pair
CT643-20	U-CyTech	20-plate	EUR 1107.6

Human IL-6 ELISPOT antibody pair
CT644-10	U-CyTech	10-plate	EUR 633.6

Human IL-6 ELISPOT antibody pair
CT644-20	U-CyTech	20-plate	EUR 1107.6

IL-8/CXCL8 Matched ELISA Antibody Pair Set, Human
MBS8118182-15Plates	MyBiosource	15Plates	EUR 600

IL-8/CXCL8 Matched ELISA Antibody Pair Set, Human
MBS8118182-5Plates	MyBiosource	5Plates	EUR 345

IL-8/CXCL8 Matched ELISA Antibody Pair Set, Human
MBS8118182-5x15Plates	MyBiosource	5x15Plates	EUR 2755

Human IL-21 ELISPOT antibody pair
CT469-10	U-CyTech	10-plate	EUR 633.6

Human IL-21 ELISPOT antibody pair
CT469-20	U-CyTech	20-plate	EUR 1107.6

Human IL-10 ELISPOT antibody pair
CT645-10	U-CyTech	10-plate	EUR 633.6

Human IL-10 ELISPOT antibody pair
CT645-20	U-CyTech	20-plate	EUR 1107.6

Human IL-13 ELISPOT antibody pair
CT646-10	U-CyTech	10-plate	EUR 633.6

Human IL-13 ELISPOT antibody pair
CT646-20	U-CyTech	20-plate	EUR 1107.6

Human IL-1β ELISPOT antibody pair
CT651-10	U-CyTech	10-plate	EUR 633.6

Human IL-1β ELISPOT antibody pair
CT651-20	U-CyTech	20-plate	EUR 1107.6

Marmoset IL-12/23p40 ELISPOT antibody pair (detects p40 subunit)
CT966-10	U-CyTech	10-plate	EUR 633.6

Marmoset IL-12/23p40 ELISPOT antibody pair (detects p40 subunit)
CT966-20	U-CyTech	20-plate	EUR 1107.6

Human IL-17A ELISPOT antibody pair
CT466-10	U-CyTech	10-plate	EUR 633.6

Human IL-17A ELISPOT antibody pair
CT466-20	U-CyTech	20-plate	EUR 1107.6

Human IL-17F ELISPOT antibody pair
CT468-10	U-CyTech	10-plate	EUR 633.6

Human IL-17F ELISPOT antibody pair
CT468-20	U-CyTech	20-plate	EUR 1107.6

Human p53R2 Antibody Pair Set
ABPR-ZB391	Creative Diagnostics	5 plates, 15 plates	Ask for price
Description: Quantitative determination of Human p53R2

Human IL-12(p70) ELISA Kit EZ-Set™ (DIY Antibody Pairs)
EZ0421	BosterBio	For 5 plates, 96 wells each, reagents only, plates are not included	EUR 500
Description: Human IL-12 (p70) ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development). Quantitate Human IL-12 (p70) in cell culture supernatants and serum.

ST2/IL-1 RL1 Matched ELISA Antibody Pair Set, Human
MBS8118185-15Plates	MyBiosource	15Plates	EUR 600

ST2/IL-1 RL1 Matched ELISA Antibody Pair Set, Human
MBS8118185-5Plates	MyBiosource	5Plates	EUR 345

ST2/IL-1 RL1 Matched ELISA Antibody Pair Set, Human
MBS8118185-5x15Plates	MyBiosource	5x15Plates	EUR 2755

Human 15-PGDH Antibody Pair Set
ABPR-ZB119	Creative Diagnostics	5 plates, 15 plates	Ask for price
Description: Quantitative determination of Human 15-PGDH

Interleukin 12/P70 (IL-12/P70) Antibody Pair
abx378027-96tests	Abbexa	96 tests	EUR 525

Interleukin 12 p40 (IL-12 p40) Antibody Pair
abx378067-96tests	Abbexa	96 tests	EUR 525

In addition, adjuvant based on nocardal cell walls have been applied in clinical studies. Because the handling of the Ajuvan by DCS can determine the type of immune response caused by the vaccine, this study aims to investigate the immature DC monocyte interaction with Nocardia Farcinica which is living or inactive in vitro and determines cellular phenotypic changes as well as changes in characteristic functions, Like phagocytosis, induction of cell proliferation, and cytokine secretion.