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Association il 12p70 and il -6: il -10 ratio with autism-related behavior at 22Q11. 2 Removal of Syndrome: Preliminary Report.

Association il - 12p70 and il -6: il -10 ratio with autism-related behavior at 22Q11. 2 Removal of Syndrome: Preliminary Report.
Posted by Curtis

 

22Q11.2 Removal of Syndrome (22Q11DS) is a genetic disorder that conveys significant risks for the development of social behavior disorders, including autism and schizophrenia. Also known as Digeorge Syndrome, 22Q11DS is the second most common genetic disorder and is characterized by high risk for immune dysfunction, up to 77% of individuals have immune deficiencies that can be identified. We hypothesize that this immune dysfunction can contribute to an increased risk of social behavior disorders seen in 22Q11DS. The current study began explaining this immune deficit and linked it to changes in behavior associated with the disorder.

The serum concentration of a series of cytokines was examined, using immunoassay multiplexay, in sixteen individuals with 22Q11DS and filtered for autism-related behavior using autism diagnostic interviews (ADI-R). This preliminary study examined the correlation between specific immune proteins and each ADI-R algorithm score (social, communication and recurring behavior). IL-1β inflammatory cytokines, as well as the ratio between IL-6 inflammatory cytokines and IL-10 anti-inflammatory cytokines, correlated with social scores (R = 0.851, p = 0.004; r = 0.580, p = 0.018).

In addition, the Inflammatory Cytokin Interferon Gamma and IL-12P70 correlated with recurring behavior (R = 0.795, p = 0.033; R = 0.774, p = 0.002). Interestingly, IL-12 has been reported to increase in autistic children. These data show a positive relationship between the severity of the behavior related to autism and the level of serum concentration of inflammatory cytokines in individuals with 22Q11DS, providing a basis for further investigation.

Transformation Macrofage M2 to M2 induced lipopolysaccharide for <em> il </ em> – <amp> 12p70 </ em> Production blocked by Candida albicans mediated the advantages of EBI3 expression.

Macrophages are heterogeneous cell populations present in all networks. Macrophages can be divided into inflammatory macrophages that are classically activated (M1) and anti-inflammatory macrophages that are activated alternatively (M2). In general it has been accepted that M1 macrophages are polarized in the inflammatory environment to produce pro-inflammatory cytokines, while M2 macrophages are involved in repairing anti-inflammation and assistance networks in wound healing. Endotoxin bacteria (lpopolysaccharide; LPS) are a strong factor in infection, which induces m1 macrophages producing the higher levels of INOS, TNFα and IL-12P70 which determines inflammatory cell responses.

M2 Macrophages can be converted into M1 macrophages after LPS stimulation to promote inflammation. Candida albicans is a commensal mushroom microorganism, which has been advised to encourage immune tolerance; However, the immune tolerance mechanism induced by albicans has not been investigated in detail. IL-35 is an anti-inflammatory cytokine that was recently identified which is a heterodimer protein consisting of genes induced by the Epstein-Barr (EBI3) and IL-12P35 virus. IL-35 shares subunit protein P35, with IL-12P70. IL-12P70 is the most effective cytokine to induce Th1 responses during inflammation. In this study, we showed that C. Albicans who was killed hot (HKC) greatly suppressed the production of IL-12P70 which was induced by LPS in M2 Macrophag.

Candida Albicans induces high level EBI3 expression in M2 Macrophage, which functions as a mechanism for the emphasis of IL-12P70 with competitive binding of general protein subunits (P35) of IL-35 and IL-12P70. To indicate that EBI3 expression has the ability to block the production of IL-12P70 intracellular, Chinese ovarian ovary cell lines (WO) with the expression of Biskutronic IL-12P40 and P35 built, followed by EBI3 ectopic expressions. Over-expression of EBI3 in the cell path that produces IL-12P70 effectively suppresses IL-12P70 production. The secretion of IL-35 was also detected in cell lines, with IL-12P70 production pressed by the deposition of rainfall. However, this secretion was not proven in M2 macrophag following stimulation by HKC.

Association <em> il </ em> - <em> 12p70 </ em> and <em> il </ em> -6: <em> il </ em> -10 ratio with autism-related behavior at 22Q11. 2 Removal of Syndrome: Preliminary Report.

This can be explained by the Constitutive Expression of the IL-35 receptor (GP130 and IL-12Rβ2) in M2 macrophages for cytokine consumption. The results we have indicated that C. albicans can suppress the response of the inflammatory host in the skin of the mucosa by suppressing the production of IL-12P70 which is induced by LPS. Lower IL-12P70 production can avoid unnecessary Th1 responsibilities to maintain immune tolerance, which may be one mechanism with C. albicans achieve a successful commensal lifestyle without having a detrimental effect on the host’s health.

Nocardia Farcinica activates human dendritic cells and induces interleukin-23 secretion (<em> il </ em> -23) than <em> il </ em> – <em> 12p70 </ em>.

Studying dendritic cell interactions (DCS) with bacteria controlled by immune response mediated by cells can reveal new adjuvants for cellular immunity induction. Murine studies and observations that infect Nocardias are dominantly immunosuppression patients have suggested that these bacteria might have an adjuvant potential.

Human IL-12p70 ELISPOT kit

CT240-PB5 5-plate
EUR 568

Human IL-12p70 ELISPOT kit

CT240-PR2 2-plate
EUR 415

Human IL-12p70 ELISPOT kit

CT240-PR5 5-plate
EUR 556

Human IL-12p70 ELISPOT kit

CT240-T2 2-plate
EUR 360

Human IL-12p70 ELISPOT kit

CT240-T5 5-plate
EUR 579

ELISA kit for Mouse IL-12p70

EK0500 96 tests
EUR 427
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse IL-12p70 in samples from serum, plasma, tissue homogenates and other biological fluids.

pAb rabbit anti-human IL-12p70

CT273 0.5 mg
EUR 207

mAb mouse anti-human IL-12p70

CT276 0.5 mg
EUR 260

Human IL-17AF ELISA antibody pair

CT565-10 10-plate
EUR 547

Human IL-17AF ELISA antibody pair

CT565-20 20-plate
EUR 932

Human IL-17A ELISA antibody pair

CT566-10 10-plate
EUR 547

Human IL-17A ELISA antibody pair

CT566-20 20-plate
EUR 932

Human IL-23 ELISA antibody pair

CT567-10 10-plate
EUR 547

Human IL-23 ELISA antibody pair

CT567-20 20-plate
EUR 932

Human IL-17F ELISA antibody pair

CT568-10 10-plate
EUR 547

Human IL-17F ELISA antibody pair

CT568-20 20-plate
EUR 932

Human IL-33 ELISA antibody pair

CT569-10 10-plate
EUR 547

Human IL-33 ELISA antibody pair

CT569-20 20-plate
EUR 932

Human IL-31 ELISA antibody pair

CT570-10 10-plate
EUR 547

Human IL-31 ELISA antibody pair

CT570-20 20-plate
EUR 932

Human IL-7 ELISA antibody pair

CT573-10 10-plate
EUR 547

Human IL-7 ELISA antibody pair

CT573-20 20-plate
EUR 932

Human IL-27 ELISA antibody pair

CT574-10 10-plate
EUR 547

Human IL-27 ELISA antibody pair

CT574-20 20-plate
EUR 932

Human IL-29 ELISA antibody pair

CT575-10 10-plate
EUR 547

Human IL-29 ELISA antibody pair

CT575-20 20-plate
EUR 932

Human IL-1β ELISA antibody pair

CT576-10 10-plate
EUR 547

Human IL-1β ELISA antibody pair

CT576-20 20-plate
EUR 932

Human IL-21 ELISA antibody pair

CT580-10 10-plate
EUR 547

Human IL-21 ELISA antibody pair

CT580-20 20-plate
EUR 932

Human IL-2 ELISA antibody pair

CT741-10 10-plate
EUR 547

Human IL-2 ELISA antibody pair

CT741-20 20-plate
EUR 932

Human IL-4 ELISA antibody pair

CT742-10 10-plate
EUR 547

Human IL-4 ELISA antibody pair

CT742-20 20-plate
EUR 932

Human IL-5 ELISA antibody pair

CT743-10 10-plate
EUR 547

Human IL-5 ELISA antibody pair

CT743-20 20-plate
EUR 932

Human IL-6 ELISA antibody pair

CT744-10 10-plate
EUR 547

Human IL-6 ELISA antibody pair

CT744-20 20-plate
EUR 932

Human IL-10 ELISA antibody pair

CT745-10 10-plate
EUR 547

Human IL-10 ELISA antibody pair

CT745-20 20-plate
EUR 932

Human IL-13 ELISA antibody pair

CT746-10 10-plate
EUR 547

Human IL-13 ELISA antibody pair

CT746-20 20-plate
EUR 932

Human IL-8 ELISA antibody pair

CT748-10 10-plate
EUR 547

Human IL-8 ELISA antibody pair

CT748-20 20-plate
EUR 932

pAb rabbit anti-human IL-12p70 Biotin-labeled

CT274 0.5 mg
EUR 347

Monkey IL-17A ELISA antibody pair

CT551-10 10-plate
EUR 547

Monkey IL-17A ELISA antibody pair

CT551-20 20-plate
EUR 932

Monkey IL-23 ELISA antibody pair

CT552-10 10-plate
EUR 547

Monkey IL-23 ELISA antibody pair

CT552-20 20-plate
EUR 932

Monkey IL-17F ELISA antibody pair

CT553-10 10-plate
EUR 547

Monkey IL-17F ELISA antibody pair

CT553-20 20-plate
EUR 932

Rat IL-4 ELISA antibody pair

CT702-10 10-plate
EUR 547

Rat IL-4 ELISA antibody pair

CT702-20 20-plate
EUR 932

Monkey IL-1β ELISA antibody pair

CT708-10 10-plate
EUR 547

Monkey IL-1β ELISA antibody pair

CT708-20 20-plate
EUR 932

Monkey IL-2 ELISA antibody pair

CT711-10 10-plate
EUR 547

Monkey IL-2 ELISA antibody pair

CT711-20 20-plate
EUR 932

Monkey IL-4 ELISA antibody pair

CT712-10 10-plate
EUR 547

Monkey IL-4 ELISA antibody pair

CT712-20 20-plate
EUR 932

Monkey IL-5 ELISA antibody pair

CT713-10 10-plate
EUR 547

Monkey IL-5 ELISA antibody pair

CT713-20 20-plate
EUR 932

Monkey IL-6 ELISA antibody pair

CT714-10 10-plate
EUR 547

Monkey IL-6 ELISA antibody pair

CT714-20 20-plate
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Monkey IL-10 ELISA antibody pair

CT715-10 10-plate
EUR 547

Monkey IL-10 ELISA antibody pair

CT715-20 20-plate
EUR 932

Monkey IL-13 ELISA antibody pair

CT716-10 10-plate
EUR 547

Monkey IL-13 ELISA antibody pair

CT716-20 20-plate
EUR 932

Monkey IL-8 ELISA antibody pair

CT718-10 10-plate
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Monkey IL-8 ELISA antibody pair

CT718-20 20-plate
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Mouse IL-4 ELISA antibody pair

CT757-10 10-plate
EUR 547

Mouse IL-4 ELISA antibody pair

CT757-20 20-plate
EUR 932

Mouse IL-2 ELISA antibody pair

CT762-10 10-plate
EUR 547

Mouse IL-2 ELISA antibody pair

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Mouse IL-6 ELISA antibody pair

CT763-10 10-plate
EUR 547

Mouse IL-6 ELISA antibody pair

CT763-20 20-plate
EUR 932

Mouse IL-5 ELISA antibody pair

CT764-10 10-plate
EUR 547

Mouse IL-5 ELISA antibody pair

CT764-20 20-plate
EUR 932

Mouse IL-10 ELISA antibody pair

CT765-10 10-plate
EUR 547

Mouse IL-10 ELISA antibody pair

CT765-20 20-plate
EUR 932

Marmoset IL-13 ELISA antibody pair

CT771-10 10-plate
EUR 547

Marmoset IL-13 ELISA antibody pair

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EUR 932

Marmoset IL-17A ELISA antibody pair

CT773-10 10-plate
EUR 547

Marmoset IL-17A ELISA antibody pair

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Marmoset IL-2 ELISA antibody pair

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Marmoset IL-2 ELISA antibody pair

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Marmoset IL-6 ELISA antibody pair

CT776-10 10-plate
EUR 547

Marmoset IL-6 ELISA antibody pair

CT776-20 20-plate
EUR 932

Human IL-17A ELISPOT antibody pair

CT466-10 10-plate
EUR 528

Human IL-17A ELISPOT antibody pair

CT466-20 20-plate
EUR 923

Human IL-17F ELISPOT antibody pair

CT468-10 10-plate
EUR 528

Human IL-17F ELISPOT antibody pair

CT468-20 20-plate
EUR 923

Human IL-21 ELISPOT antibody pair

CT469-10 10-plate
EUR 528

In addition, adjuvant based on nocardal cell walls have been applied in clinical studies. Because the handling of the Ajuvan by DCS can determine the type of immune response caused by the vaccine, this study aims to investigate the immature DC monocyte interaction with Nocardia Farcinica which is living or inactive in vitro and determines cellular phenotypic changes as well as changes in characteristic functions, Like phagocytosis, induction of cell proliferation, and cytokine secretion.

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